Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AVPR1B | P47901 | 1/20 | 0.39 |
| ▸ | TRIM58 | Q8NG06 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.38 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.38 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.38 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.36 |
| ▸ | HTR4 | Q13639 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | SYK | P43405 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 2/20 | 0.36 |
| ▸ | NPR1 | P16066 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 2/20 | 0.35 |
| ▸ | MOK | Q9UQ07 | 1/20 | 0.35 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3334893 | 0.85 | MAPK14 (0.49) | AVPR1BMAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL5146071 | 0.81 | MAP3K11 (0.45) | AVPR1BTRIM58MAPK14MAPK13MAPK12 | |
| SCHEMBL3333859 | 0.79 | TRIM58 (0.55) | TRIM58MAPK14KCNH2HTR4HTR2A | |
| SCHEMBL5131263 | 0.79 | KCNH2 (0.44) | TRIM58PIK3CAKCNH2HTR4HTR2A | |
| SCHEMBL3336361 | 0.78 | MOK (0.51) | PIK3CAKDM4EMOKGRM4 | |
| SCHEMBL3341530 | 0.78 | PIK3CA (0.44) | TRIM58PIK3CAKDM4EALDH1A1HPGD | |
| SCHEMBL3335966 | 0.75 | ADORA3 (0.40) | PIK3CANPR1 | |
| SCHEMBL3339979 | 0.74 | KIT (0.48) | MAPK14MAPK13MAPK12MAPK11PIK3CA | |
| SCHEMBL5131696 | 0.73 | TRIM58 (0.47) | TRIM58PIK3CAKCNH2HTR4SYK | |
| SCHEMBL3337025 | 0.72 | TRIM58 (0.56) | TRIM58KCNH2HTR4KDM4ENPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008009077-A2 | 4,6-DL- AND 2,4,6-TRISUBSTITUTED QUINAZOLINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS USEFUL FOR TREATING VIRAL INFECTIONS | GILEAD SCIENCES, INC. (US) | 2008-01-24 | — | — | WO | claimed |