Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BDKRB1 | P46663 | 4/20 | 0.48 |
| ▸ | PSEN1 | P49768 | 14/20 | 0.45 |
| ▸ | PSEN2 | P49810 | 14/20 | 0.45 |
| ▸ | APH1B | Q8WW43 | 14/20 | 0.45 |
| ▸ | NCSTN | Q92542 | 14/20 | 0.45 |
| ▸ | APH1A | Q96BI3 | 14/20 | 0.45 |
| ▸ | PSENEN | Q9NZ42 | 14/20 | 0.45 |
| ▸ | APP | P05067 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5128681 | 0.89 | BDKRB1 (0.53) | BDKRB1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL5132282 | 0.85 | RORC (0.49) | BDKRB1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL5126164 | 0.84 | RECQL (0.47) | — | |
| SCHEMBL5132569 | 0.84 | RECQL (0.44) | — | |
| SCHEMBL3406152 | 0.82 | PSEN1 (0.49) | BDKRB1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL3402856 | 0.82 | BDKRB1 (0.47) | BDKRB1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL4113323 | 0.82 | PSEN1 (0.49) | BDKRB1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL3405283 | 0.81 | APP (0.47) | BDKRB1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL4383315 | 0.81 | APP (0.49) | BDKRB1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL5128428 | 0.80 | ALDH1A1 (0.45) | BDKRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080249128-A1 | Substituted Sulfonamide Compounds | GRUENENTHAL GMBH (DE) | 2008-10-09 | — | — | US | claimed |
| US-8580965-B2 | Substituted sulfonamide compounds | GRUENENTHAL GMBH (DE) | 2013-11-12 | — | — | US | disclosed |
| US-20080249128-A1 | Substituted Sulfonamide Compounds | GRUENENTHAL GMBH (DE) | 2008-10-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080249128-A1 | Substituted Sulfonamide Compounds | BDKRB1, BDKRB2, NPSR1 | BDKRB1 1/4885PSEN1 784/4885PSEN2 878/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.