Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 6/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 7/20 | 0.39 |
| ▸ | PDE4A | P27815 | 7/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3631682 | 0.75 | ERN1 (0.46) | KMT2ARECQL | |
| SCHEMBL3677096 | 0.74 | PDE4D (0.49) | PDE4DKMT2APDE4BPDE4APDE4C | |
| SCHEMBL7375826 | 0.72 | PDE4B (0.57) | PDE4DRECQLPDE4BPDE4APDE4C | |
| SCHEMBL3681993 | 0.72 | PDE4D (0.50) | PDE4DKMT2APDE4BPDE4APDE4C | |
| SCHEMBL1832013 | 0.71 | ERN1 (0.46) | KMT2A | |
| SCHEMBL21822829 | 0.71 | ERN1 (0.39) | KMT2A | |
| SCHEMBL7151009 | 0.70 | AOC3 (0.49) | KMT2APOLB | |
| SCHEMBL12479001 | 0.70 | PTGS1 (0.42) | — | |
| SCHEMBL21823724 | 0.69 | ERN1 (0.51) | PDE4DKMT2APDE4BPDE4APDE4C | |
| SCHEMBL8748732 | 0.69 | KMT2A (0.52) | PDE4DKMT2APDE4BPDE4APDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008006051-A2 | BICYCLIC HETEROARYL INHIBITORS OF PDE4 | GOVEK STEVEN P (US) | 2008-01-10 | — | — | WO | disclosed |