Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR2 | P21452 | 1/20 | 0.37 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.36 |
| ▸ | HTR4 | Q13639 | 11/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5053752 | 0.76 | GRM5 (0.38) | TACR2CHRM4CHRM2HTR4CYP3A4 | |
| SCHEMBL5050427 | 0.76 | TACR2 (0.40) | TACR2CHRM4CHRM2HTR4CYP3A4 | |
| SCHEMBL5053738 | 0.76 | TACR2 (0.38) | TACR2CHRM4CHRM2HTR4CYP3A4 | |
| SCHEMBL4275691 | 0.69 | TACR2 (0.57) | TACR2MEN1KMT2A | |
| SCHEMBL4271169 | 0.68 | TACR2 (0.43) | TACR2HTR4CYP3A4CYP2D6MEN1 | |
| SCHEMBL5051949 | 0.67 | TACR2 (0.37) | TACR2CHRM4CHRM2HTR4CYP3A4 | |
| SCHEMBL10955675 | 0.63 | POLB (0.50) | MEN1KMT2AACHE | |
| SCHEMBL8231635 | 0.62 | SIGMAR1 (0.58) | TACR2MEN1KMT2AACHE | |
| Hydrochloric Acid SCHEMBL11643444 | 0.62 | ALDH1A1 (0.49) | MEN1KMT2AACHE | |
| SCHEMBL15757380 | 0.61 | HTR2B (0.51) | TACR2MEN1KMT2AACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1976841-A1 | HETEROCYCLIC AMIDE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS | Neuromed Pharmaceuticals, Ltd. (CA) | 2008-10-08 | — | — | EP | claimed |
| WO-2007071035-A1 | HETEROCYCLIC AMIDE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS | NEUROMED PHARMACEUTICALS LTD. (CA) | 2007-06-28 | — | — | WO | claimed |