Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 1/20 | 0.38 |
| ▸ | GRM7 | Q14831 | 1/20 | 0.38 |
| ▸ | GRM3 | Q14832 | 1/20 | 0.38 |
| ▸ | TACR2 | P21452 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | DRD1 | P21728 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.36 |
| ▸ | HTR4 | Q13639 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5053738 | 0.77 | TACR2 (0.38) | TACR2POLBCYP2D6CHRM2CHRM4 | |
| SCHEMBL5050427 | 0.77 | TACR2 (0.40) | TACR2CYP2D6CHRM2CHRM4HTR4 | |
| SCHEMBL5133014 | 0.76 | TACR2 (0.37) | TACR2CYP2D6CHRM2KCNH2CHRM4 | |
| SCHEMBL4279734 | 0.67 | TACR2 (0.60) | GRM5GRM7GRM3TACR2POLB | |
| SCHEMBL5047955 | 0.65 | CACNA1G (0.39) | GRM5GRM7GRM3TACR2POLB | |
| SCHEMBL6003228 | 0.65 | DRD3 (0.42) | CYP2D6CHRM2HTR1AADRA2ACHRM1 | |
| SCHEMBL4275673 | 0.65 | TACR2 (0.46) | GRM5GRM7GRM3TACR2POLB | |
| SCHEMBL8237608 | 0.65 | SIGMAR1 (0.39) | TACR2POLBSLC6A2SLC6A3HTR4 | |
| SCHEMBL8231635 | 0.63 | SIGMAR1 (0.58) | TACR2HTR1AADRA2AHRH3 | |
| SCHEMBL15757380 | 0.62 | HTR2B (0.51) | TACR2POLBOPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1976841-A1 | HETEROCYCLIC AMIDE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS | Neuromed Pharmaceuticals, Ltd. (CA) | 2008-10-08 | — | — | EP | claimed |
| WO-2007071035-A1 | HETEROCYCLIC AMIDE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS | NEUROMED PHARMACEUTICALS LTD. (CA) | 2007-06-28 | — | — | WO | claimed |