Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.59 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.48 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.48 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.35 |
| ▸ | BCHE | P06276 | 1/20 | 0.35 |
| ▸ | TYR | P14679 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | P4HB | P07237 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | GMNN | O75496 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9068507 | 0.85 | TSHR (0.50) | TSHRGABRA1GABRB2NISCHPOLB | |
| SCHEMBL17571740 | 0.76 | KAT2B (0.44) | TSHRNISCHHPGDGAALMNA | |
| SCHEMBL17571739 | 0.76 | NISCH (0.70) | NISCHNFKB1BLMHIF1AAOC3 | |
| SCHEMBL11285544 | 0.74 | POLB (0.44) | TSHRNISCHPOLBHPGDGAA | |
| SCHEMBL296591 | 0.74 | TSHR (0.68) | TSHRGABRA1GABRB2POLBHPGD | |
| SCHEMBL20721726 | 0.74 | TSHR (1.00) | TSHRGABRA1GABRB2POLBHPGD | |
| SCHEMBL29860994 | 0.74 | TSHR (0.68) | TSHRGABRA1GABRB2POLBHPGD | |
| SCHEMBL301684 | 0.74 | GABRA1 (0.56) | TSHRGABRA1GABRB2NISCHPOLB | |
| SCHEMBL282162 | 0.74 | TSHR (1.00) | TSHRGABRA1GABRB2POLBHPGD | |
| SCHEMBL282881 | 0.74 | TSHR (0.68) | TSHRGABRA1GABRB2POLBHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108250047-A | A kind of 2,6- di-t-butyls are to the preparation method of alkyl phenol | 江苏迈达新材料股份有限公司 | 2018-07-06 | — | — | CN | disclosed |
| US-20120295973-A1 | METHODS AND COMPOSITIONS OF DERIVATIVES OF PROBUCOL FOR THE TREATMENT OF DIABETES | SALUTRIA PHARMACEUTICALS LLC | 2012-11-22 | — | — | US | disclosed |
| US-8252840-B2 | administering monoesters of probucol, such as AGI-1067, succinobucol | SALUTRIA PHARMACEUTICALS LLC (US) | 2012-08-28 | — | — | US | disclosed |
| CN-100445340-C | Curable coating composition | TORAY FINE CHEMICAL CO LTD (JP) | 2008-12-24 | — | — | CN | disclosed |
| US-20080280979-A1 | Methods and Compositions of Derivatives of Probucol for the Treatment of Diabetes | CRABTREE ACQUISITION CO, LLC | 2008-11-13 | — | — | US | disclosed |
| CN-1509321-A | Curable coating composition | ������ѧ��ʽ���� | 2004-06-30 | — | — | CN | disclosed |
| WO-2002067916-A3 | PHARMACEUTICAL SALTS | GRUENENTHAL GMBH (DE) | 2003-12-18 | — | — | WO | disclosed |
| WO-2002067916-A2 | PHARMACEUTICAL SALTS | Grünenthal GmbH (DE) | 2002-09-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080280979-A1 | Methods and Compositions of Derivatives of Probucol for the Treatment of Diabetes | PNLIP, SLC5A2, LIPC | TSHR 3212/4885GABRA1 424/4885GABRB2 406/4885 |
| US-20120295973-A1 | METHODS AND COMPOSITIONS OF DERIVATIVES OF PROBUCOL FOR THE TREATMENT OF DIABETES | PNLIP, SLC5A2, LIPC | TSHR 3212/4885GABRA1 424/4885GABRB2 406/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.