Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 14/20 | 0.44 |
| ▸ | RAB9A | P51151 | 13/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.44 |
| ▸ | TP53 | P04637 | 5/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.44 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.44 |
| ▸ | RELA | Q04206 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL513204 | 0.79 | HDAC6 (0.44) | NPC1RAB9ASMN1; SMN2TP53ALDH1A1 | |
| SCHEMBL513425 | 0.78 | NPC1 (0.45) | NPC1RAB9ASMN1; SMN2TP53ALDH1A1 | |
| SCHEMBL514009 | 0.78 | HDAC1 (0.48) | NPC1RAB9ASMN1; SMN2TP53ALDH1A1 | |
| SCHEMBL512821 | 0.78 | CA2 (0.41) | NPC1RAB9AALDH1A1L3MBTL1TDP1 | |
| SCHEMBL514330 | 0.78 | NPC1 (0.46) | NPC1RAB9ASMN1; SMN2TP53LMNA | |
| SCHEMBL512899 | 0.76 | KDM4E (0.48) | NPC1RAB9ASMN1; SMN2MAPK1TP53 | |
| SCHEMBL512797 | 0.76 | KDM4E (0.47) | NPC1RAB9ASMN1; SMN2TP53ALDH1A1 | |
| SCHEMBL512093 | 0.76 | NPC1 (0.41) | NPC1RAB9ASMN1; SMN2MAPK1TP53 | |
| SCHEMBL513461 | 0.75 | CCR1 (0.37) | NPC1RAB9ASMN1; SMN2TP53ALDH1A1 | |
| SCHEMBL513467 | 0.75 | HSD17B10 (0.42) | NPC1RAB9ASMN1; SMN2TP53ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120028931-A1 | HETEROCYCLIC M-GLU5 ANTAGONISTS | RECORDATI IRELAND LIMITED (IE) | 2012-02-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120028931-A1 | HETEROCYCLIC M-GLU5 ANTAGONISTS | OPRM1, GRM5, OPRD1 | NPC1 4017/4885RAB9A 2058/4885SMN1; SMN2 411/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.