Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 6/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.64 |
| ▸ | GSK3B | P49841 | 5/20 | 0.55 |
| ▸ | ACHE | P22303 | 2/20 | 0.51 |
| ▸ | BCHE | P06276 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 5/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | CASP1 | P29466 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11987279 | 0.72 | RAB9A (0.57) | RAB9AKDM4ENPC1L3MBTL1GPR55 | |
| SCHEMBL455366 | 0.72 | GSK3B (1.00) | RAB9AKDM4EGSK3BACHENPC1 | |
| SCHEMBL12630024 | 0.70 | GSK3B (0.56) | RAB9AKDM4EGSK3BACHENPC1 | |
| SCHEMBL27837899 | 0.70 | GSK3B (0.81) | RAB9AKDM4EGSK3BACHENPC1 | |
| SCHEMBL12076780 | 0.70 | MAPT (0.50) | RAB9AKDM4EGSK3BNPC1L3MBTL1 | |
| SCHEMBL29808284 | 0.70 | MAPT (0.50) | RAB9AKDM4EGSK3BNPC1L3MBTL1 | |
| SCHEMBL2179323 | 0.69 | CDC7 (0.69) | RAB9AKDM4EBCL2 | |
| SCHEMBL3490613 | 0.69 | GSK3B (0.58) | RAB9AKDM4EGSK3BACHEBCHE | |
| SCHEMBL27855690 | 0.69 | GSK3B (0.63) | RAB9AKDM4EGSK3BNPC1L3MBTL1 | |
| SCHEMBL29923403 | 0.69 | PLAU (0.60) | RAB9AKDM4EBCHENPC1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1994002-A1 | PIPERIDINE DERIVATIVES, THEIR PROCESS FOR PREPARATION, THEIR USE AS THERAPEUTIC AGENTS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | AstraZeneca AB (SE) | 2008-11-26 | — | — | EP | disclosed |
| WO-2007102767-A1 | PIPERIDINE DERIVATIVES, THEIR PROCESS FOR PREPARATION, THEIR USE AS THERAPEUTIC AGENTS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | ASTRAZENECA AB (SE) | 2007-09-13 | — | — | WO | disclosed |