SCHEMBL455366

SCHEMBL455366

c1ccc(Nc2nnc(-c3ccccc3)o2)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GSK3B P49841 9/20 1.00
RAB9A P51151 4/20 0.78
NPC1 O15118 3/20 0.78
SMN1; SMN2 Q16637 3/20 0.78
MEN1 O00255 1/20 0.78
TP53 P04637 1/20 0.78
MAPK1 P28482 1/20 0.78
KMT2A Q03164 1/20 0.78
ACHE P22303 1/20 0.67
HDAC6 Q9UBN7 1/20 0.66
ALDH1A1 P00352 1/20 0.61
PTGS2 P35354 1/20 0.61
HTT P42858 1/20 0.61
L3MBTL1 Q9Y468 1/20 0.61
KDM4E B2RXH2 1/20 0.59
SPHK2 Q9NRA0 1/20 0.55
EPHX2 P34913 1/20 0.54
FLT1 P17948 1/20 0.51
FLT4 P35916 1/20 0.51
KDR P35968 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27837899 0.90 GSK3B (0.81) GSK3BRAB9ANPC1SMN1; SMN2MEN1
SCHEMBL29011091 0.88 RAB9A (0.88) GSK3BRAB9ANPC1SMN1; SMN2MEN1
SCHEMBL27855638 0.88 RAB9A (1.00) GSK3BRAB9ANPC1SMN1; SMN2MEN1
SCHEMBL27837901 0.88 GSK3B (0.78) GSK3BRAB9ANPC1SMN1; SMN2MEN1
SCHEMBL28615859 0.88 GSK3B (0.78) GSK3BRAB9ANPC1SMN1; SMN2MEN1
SCHEMBL28622100 0.88 GSK3B (0.78) GSK3BRAB9ANPC1SMN1; SMN2MEN1
SCHEMBL30386353 0.88 GSK3B (0.78) GSK3BRAB9ANPC1SMN1; SMN2MEN1
SCHEMBL17377349 0.88 GSK3B (0.78) GSK3BRAB9ANPC1SMN1; SMN2MEN1
SCHEMBL17377357 0.84 GSK3B (0.86) GSK3BRAB9ANPC1SMN1; SMN2MEN1
SCHEMBL28629744 0.84 GSK3B (0.71) GSK3BRAB9ANPC1SMN1; SMN2MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 79 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4073235-A1 IN VITRO EXPANSION OF DOPAMINERGIC SUBTYPE NEURONAL PROGENITORS DERIVED FROM PLURIPOTENT STEM CELLS Wisconsin Alumni Research Foundation (US) 2022-10-19 EP claimed
CN-115151633-A In vitro expansion of pluripotent stem cell-derived dopaminergic subtype neuronal progenitor cells 威斯康星校友研究基金会 2022-10-04 CN claimed
US-20220186183-A1 NOVEL GLIA-LIKE CELLS DIFFERENATIATED FROM SOMATIC CELLS, PREPARATION METHOD THEREFOR, COCKTAIL COMPOSITION FOR PREPARING SAME, CELL THERAPEUTIC AGENT FOR PREVENTING OR TREATING NEUROLOGICAL DISORDERS, COMPRISING SAME, AND METHOD FOR PREVENTING AND TREATING NEUROLOGICAL DISORDERS BY ADMINISTERING SAME Cellapeutics Bio (KR) 2022-06-16 US claimed
EP-3907279-A1 NOVEL GLIA-LIKE CELLS DIFFERENTIATED FROM SOMATIC CELLS, PREPARATION METHOD THEREFOR, COCKTAIL COMPOSITION FOR PREPARING SAME, CELL THERAPEUTIC AGENT FOR PREVENTING OR TREATING NEUROLOGICAL DISORDERS, COMPRISING SAME, AND METHOD FOR PREVENTING AND TREATING NEUROLOGICAL DISORDERS BY ADMINISTERING SAME Cellapeutics Bio (KR) 2021-11-10 EP claimed
US-20190032018-A1 REPROGRAMMING CARDIOMYOCYTES WITH ONE TRANSCRIPTION FACTOR THE J. DAVID GLADSTONE INSTITUTES, A TESTAMENTARY TRUST ESTABLISHED UNDER THE WILL OF J. DAVID GLADSTONE 2019-01-31 US claimed
WO-2018160028-A1 MEDIUM COMPOSITION FOR NEURON DIFFERENTIATION AND METHOD FOR DIFFERENTIATING SOMATIC CELLS INTO NEURONS USING SAME MEDIUM COMPOSITION 주식회사 셀라토즈테라퓨틱스 2018-09-07 WO claimed
WO-2018155913-A1 METHOD FOR DIFFERENTIATION INTO SKELETAL MUSCLE CELL USING LOW-MOLECULAR WEIGHT COMPOUND 성균관대학교산학협력단 2018-08-30 WO claimed
US-20160251624-A1 REPROGRAMMING CARDIOMYOCYTES WITH ONE TRANSCRIPTION FACTOR THE J. DAVID GLADSTONE INSTITUTES, A TESTAMENTARY TRUST ESTABLISHED UNDER THE WILL OF J. DAVID GLADSTONE 2016-09-01 US claimed
EP-3060649-A1 REPROGRAMMING CARDIOMYOCYTES WITH ONE TRANSCRIPTION FACTOR The J. David Gladstone Institutes, A Testamentary Trust Established under The Will of J. David Gladstone (US) 2016-08-31 EP claimed
EP-3043822-A1 COMPOSITIONS FOR PREPARING CARDIOMYOCYTES The J. David Gladstone Institutes, A Testamentary Trust Established under The Will of J. David Gladstone (US) 2016-07-20 EP claimed
US-20160186141-A1 SMALL MOLECULE CELLULAR REPROGRAMMING TO GENERATE CARDIOMYOCYTES The J. David Gladstone Institutes, a testamentary trust established under the Will of J. David Glad 2016-06-30 US claimed
WO-2015061568-A1 REPROGRAMMING CARDIOMYOCYTES WITH ONE TRANSCRIPTION FACTOR THE J. DAVID GLADSTONE INSTITUTES, A TESTAMENTARY TRUST ESTABLISHED UNDER THE WILL OF J. DAVID GLADSTONE (US) 2015-04-30 WO claimed
WO-2015038704-A1 COMPOSITIONS FOR PREPARING CARDIOMYOCYTES THE J. DAVID GLADSTONE INSTITUTES, A TESTAMENTARY TRUST ESTABLISHED UNDER THE WILL OF J. DAVID GLADSTONE (US) 2015-03-19 WO claimed
US-8883502-B2 Expandable cell source of neuronal stem cell populations and methods for obtaining and using them THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2014-11-11 US claimed
US-20130236436-A1 EXPANDABLE CELL SOURCE OF NEURONAL STEM CELL POPULATIONS AND METHODS FOR OBTAINING AND USNIG THEM ZHANG KANG (US) 2013-09-12 US claimed
WO-2012034101-A2 EXPANDABLE CELL SOURCE OF NEURONAL STEM CELL POPULATIONS AND METHODS FOR OBTAINING AND USING THEM THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2012-03-15 WO claimed
WO-2025106671-A1 PERSONALIZED PROGENITOR CELLS IMMORTA BIO, INC. (US) 2025-05-22 WO disclosed
US-12104169-B2 Chemical reprogramming to generate neuronal cells THE J. DAVID GLADSTONE INSTITUTES, A TESTAMENTARY TRUST ESTABLISHED UNDER THE WILL OF J. DAVID GLADSTONE (US) 2024-10-01 US disclosed
US-20100330069-A1 HETEROCYCLIC COMPOUNDS AND METHODS OF USE TARGEGEN, INC. (US) 2010-12-30 US disclosed
US-7652051-B2 Heterocyclic compounds and methods of use TARGEGEN, INC. (US) 2010-01-26 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220186183-A1 NOVEL GLIA-LIKE CELLS DIFFERENATIATED FROM SOMATIC CELLS, PREPARATION METHOD THEREFOR, COCKTAIL COMPOSITION FOR PREPARING SAME, CELL THERAPEUTIC AGENT FOR PREVENTING OR TREATING NEUROLOGICAL DISORDERS, COMPRISING SAME, AND METHOD FOR PREVENTING AND TREATING NEUROLOGICAL DISORDERS BY ADMINISTERING SAME GMFG, HGF, BDNF GSK3B 293/4885RAB9A 3482/4885NPC1 1420/4885
US-20160251624-A1 REPROGRAMMING CARDIOMYOCYTES WITH ONE TRANSCRIPTION FACTOR POU2F1, POU5F1, POU2F2 GSK3B 1412/4885RAB9A 3375/4885NPC1 4503/4885
US-20160186141-A1 SMALL MOLECULE CELLULAR REPROGRAMMING TO GENERATE CARDIOMYOCYTES MYLK2, TNNI3, TNNT2 GSK3B 795/4885RAB9A 1294/4885NPC1 4035/4885
US-20190032018-A1 REPROGRAMMING CARDIOMYOCYTES WITH ONE TRANSCRIPTION FACTOR POU2F1, POU5F1, POU2F2 GSK3B 1412/4885RAB9A 3375/4885NPC1 4503/4885
US-12104169-B2 Chemical reprogramming to generate neuronal cells CHAT, DCX, NES GSK3B 846/4885RAB9A 1481/4885NPC1 2242/4885
US-20100330069-A1 HETEROCYCLIC COMPOUNDS AND METHODS OF USE AADAC, NISCH, PAICS GSK3B 2586/4885RAB9A 4578/4885NPC1 3400/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.