Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Dl-Phenylalanine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC7A5 | Q01650 | 3/20 | 0.59 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.59 |
| ▸ | ALPI | P09923 | 1/20 | 0.59 |
| ▸ | PKM | P14618 | 1/20 | 0.59 |
| ▸ | XIAP | P98170 | 1/20 | 0.59 |
| ▸ | CTSC | P53634 | 2/20 | 0.53 |
| ▸ | SLC1A3 | P43003 | 2/20 | 0.46 |
| ▸ | SLC1A2 | P43004 | 2/20 | 0.46 |
| ▸ | SLC1A1 | P43005 | 2/20 | 0.46 |
| ▸ | DPP4 | P27487 | 3/20 | 0.45 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.45 |
| ▸ | DPP9 | Q86TI2 | 2/20 | 0.45 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.45 |
| ▸ | FAP | Q12884 | 1/20 | 0.43 |
| ▸ | ACE | P12821 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | HTR2B | P41595 | 1/20 | 0.43 |
| ▸ | SLC15A1 | P46059 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phenylalanine SCHEMBL148429 | 1.00 | SLC7A5 (0.59) | SLC7A5PTGS1ALPIPKMXIAP | |
| Dl-Phenylalanine SCHEMBL498385 | 1.00 | SLC7A5 (0.59) | SLC7A5PTGS1ALPIPKMXIAP | |
| Dl-Phenylalanine SCHEMBL22468204 | 1.00 | SLC7A5 (0.59) | SLC7A5PTGS1ALPIPKMXIAP | |
| Phenylalanine SCHEMBL28136484 | 1.00 | SLC7A5 (0.59) | SLC7A5PTGS1ALPIPKMXIAP | |
| D-Phenylalanine SCHEMBL2184336 | 1.00 | SLC7A5 (0.59) | SLC7A5PTGS1ALPIPKMXIAP | |
| Phenylalanine SCHEMBL2478802 | 1.00 | SLC7A5 (0.59) | SLC7A5PTGS1ALPIPKMXIAP | |
| Dl-Phenylalanine SCHEMBL2478801 | 1.00 | SLC7A5 (0.59) | SLC7A5PTGS1ALPIPKMXIAP | |
| Dl-Phenylalanine SCHEMBL21899689 | 0.95 | SLC7A5 (0.54) | SLC7A5PTGS1ALPIPKMXIAP | |
| Phenylalanine SCHEMBL4405170 | 0.95 | SLC7A5 (0.54) | SLC7A5PTGS1ALPIPKMXIAP | |
| Dl-Phenylalanine SCHEMBL21899690 | 0.95 | SLC7A5 (0.54) | SLC7A5PTGS1ALPIPKMXIAP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118304208-A | Use of cyclic dipeptides for skin whitening | 陕西慧康生物科技有限责任公司 | 2024-07-09 | — | — | CN | claimed |
| CN-116790504-A | Culture medium, method and application for culturing GBF1 knockout ST cells | 天信和(苏州)生物科技有限公司 | 2023-09-22 | — | — | CN | claimed |
| CN-118304208-A | Use of cyclic dipeptides for skin whitening | 陕西慧康生物科技有限责任公司 | 2024-07-09 | — | — | CN | disclosed |
| CN-118159294-A | Combination therapy for the treatment of cancer | 葛兰素史密斯克莱知识产权发展有限公司 | 2024-06-07 | — | — | CN | disclosed |
| CN-116790504-A | Culture medium, method and application for culturing GBF1 knockout ST cells | 天信和(苏州)生物科技有限公司 | 2023-09-22 | — | — | CN | disclosed |
| CN-116751711-A | Bacillus atrophaeus LB6-2 and application thereof | 新疆农业科学院植物保护研究所 | 2023-09-15 | — | — | CN | disclosed |
| CN-116686847-A | Metabolite of bacillus atrophaeus LB6-2 and application thereof | 新疆农业科学院植物保护研究所 | 2023-09-05 | — | — | CN | disclosed |
| CN-114088855-A | Feces biomarker for early diagnosis of tibial cartilage dysplasia of broiler chicken and application thereof | 河南农业大学 | 2022-02-25 | — | — | CN | disclosed |
| CN-106220709-B | A kind of easy synthetic peptide through blood-brain barrier | 武汉弘跃医药科技有限公司 | 2019-09-17 | — | — | CN | disclosed |
| CN-104780919-B | Antibacterial comprising cis- ring (L-Leu-L-PROLINE) or cis- ring (L-phenylalanine-L-PROLINE) and antiviral composition and its manufacturing method | 首尔大学产学协力团 | 2018-12-11 | — | — | CN | disclosed |
| CN-104780919-B | Antibacterial comprising cis- ring (L-Leu-L-PROLINE) or cis- ring (L-phenylalanine-L-PROLINE) and antiviral composition and its manufacturing method | 首尔大学产学协力团 | 2018-12-11 | — | — | CN | disclosed |
| CN-104109190-B | It is a kind of to prepare single polypeptide-Zn（Ⅱ）The method of complex | 广州大学 | 2018-11-09 | — | — | CN | disclosed |
| CN-106893687-A | Production antibacterial, antimycotic and antivirotic Bacillus acidi lactici IR WEE 01 | 河北路克希德生物科技有限公司 | 2017-06-27 | — | — | CN | disclosed |
| CN-103517987-B | Change type lipase and manufacture method thereof and use the reaction of this enzyme | 宇部兴产株式会社 | 2016-10-12 | — | — | CN | disclosed |
| CN-103059031-A | High-pressure reverse-phase preparation separation technology of cyclic dipeptide C7 contained in phellinus igniarius | UNIV QINGDAO AGRICULTURAL | 2013-04-24 | — | — | CN | disclosed |
| EP-1986665-A2 | MICROALGAE-DERIVED COMPOSITIONS FOR IMPROVING THE HEALTH AND APPEARANCE OF SKIN | Solazyme, Inc. (US) | 2008-11-05 | — | — | EP | disclosed |
| WO-2007084769-A2 | MICROALGAE-DERIVED COMPOSITIONS FOR IMPROVING THE HEALTH AND APPEARANCE OF SKIN | SOLAZYME, INC. (US) | 2007-07-26 | — | — | WO | disclosed |