Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | REN | P00797 | 3/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | BACE1 | P56817 | 1/20 | 0.33 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.33 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL663208 | 0.99 | KDM4E (0.37) | MEN1KMT2AKDM4EGAAHTT | |
| Ammonia Solution, Strong SCHEMBL1072026 | 0.92 | MEN1 (0.38) | MEN1KMT2AKDM4EGAAHTT | |
| SCHEMBL661848 | 0.91 | MEN1 (0.38) | MEN1KMT2AKDM4EGAAHTT | |
| SCHEMBL27973124 | 0.88 | ALDH1A1 (0.41) | MEN1KMT2AKDM4EGAAHTT | |
| SCHEMBL5134892 | 0.86 | REN (0.33) | MEN1KMT2ARENCYP3A4BACE1 | |
| SCHEMBL660901 | 0.84 | REN (0.41) | MEN1KMT2AKDM4EGAAHTT | |
| SCHEMBL1081062 | 0.84 | MEN1 (0.36) | MEN1KMT2AKDM4EGAAHTT | |
| SCHEMBL1518881 | 0.84 | KDM4E (0.38) | MEN1KMT2AKDM4EGAAHTT | |
| SCHEMBL10186643 | 0.83 | SKP2 (0.44) | MEN1KMT2AKDM4EHTTCYP3A4 | |
| SCHEMBL1072293 | 0.82 | KMT2A (0.35) | MEN1KMT2AKDM4EGAAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1910272-A1 | RENIN INHIBITORS | Merck Frosst Canada Ltd. (CA) | 2008-04-16 | — | — | EP | disclosed |
| WO-2007009250-A1 | RENIN INHIBITORS | MERCK FROSST CANADA LTD. (CA) | 2007-01-25 | — | — | WO | disclosed |