Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SKP2 | Q13309 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | CYP4Z1 | Q86W10 | 1/20 | 0.39 |
| ▸ | CYP4F11 | Q9HBI6 | 1/20 | 0.39 |
| ▸ | CYP4F12 | Q9HCS2 | 1/20 | 0.39 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.38 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.38 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.38 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10186648 | 0.91 | MEN1 (0.38) | CYP2D6CYP2C9SPHK1CYP1A2CYP2C19 | |
| SCHEMBL663208 | 0.85 | KDM4E (0.37) | CYP2D6CYP2C9CYP3A4CYP1A2CYP2C19 | |
| SCHEMBL12138172 | 0.85 | MAPK14 (0.36) | CYP2D6CYP2C9CYP1A2CYP2C19RAB9A | |
| SCHEMBL10186616 | 0.84 | SPHK1 (0.40) | SKP2SPHK1S1PR4S1PR1S1PR3 | |
| Ammonia Solution, Strong SCHEMBL5134889 | 0.83 | MEN1 (0.36) | CYP2D6CYP2C9CYP3A4CYP1A2CYP2C19 | |
| SCHEMBL661848 | 0.81 | MEN1 (0.38) | CYP2D6CYP2C9CYP1A2CYP2C19RAB9A | |
| Ammonia Solution, Strong SCHEMBL1072026 | 0.80 | MEN1 (0.38) | CYP2D6CYP2C9CYP1A2CYP2C19RAB9A | |
| SCHEMBL11366320 | 0.77 | SKP2 (0.58) | SKP2CYP2D6CYP2C9CYP3A4CYP1A2 | |
| SCHEMBL10186619 | 0.77 | ALDH1A1 (0.50) | SPHK1RAB9AMEN1KMT2ACNR1 | |
| SCHEMBL23545671 | 0.76 | TAAR1 (0.44) | CYP2D6CYP2C9CYP1A2CYP2C19RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120046293-A1 | RENIN INHIBITORS | MERCK FROSST CANADA LTD. (CA) | 2012-02-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120046293-A1 | RENIN INHIBITORS | REN, ACE, AGTR1 | SKP2 2383/4885CYP2D6 350/4885CYP2C9 634/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.