Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES1 | P23141 | 1/20 | 0.47 |
| ▸ | CSF1R | P07333 | 2/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
| ▸ | CASP14 | P31944 | 1/20 | 0.40 |
| ▸ | CASP3 | P42574 | 1/20 | 0.40 |
| ▸ | CASP2 | P42575 | 1/20 | 0.40 |
| ▸ | CASP4 | P49662 | 1/20 | 0.40 |
| ▸ | CASP5 | P51878 | 1/20 | 0.40 |
| ▸ | CASP7 | P55210 | 1/20 | 0.40 |
| ▸ | CASP9 | P55211 | 1/20 | 0.40 |
| ▸ | CASP6 | P55212 | 1/20 | 0.40 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.40 |
| ▸ | CASP12 | Q6UXS9 | 1/20 | 0.40 |
| ▸ | CASP10 | Q92851 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 4/20 | 0.39 |
| ▸ | KDR | P35968 | 3/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5135369 | 0.93 | CES1 (0.48) | CES1CSF1RHDAC1HDAC8HDAC6 | |
| SCHEMBL5135024 | 0.74 | ADORA2A (0.43) | EGFRNPC1RAB9ASMN1; SMN2ADORA2A | |
| SCHEMBL5135030 | 0.72 | GAPDH (0.42) | CES1EGFRKDRPDGFRBNPC1 | |
| SCHEMBL5664809 | 0.72 | LDHA (0.40) | KDRNPC1RAB9AADORA2A | |
| SCHEMBL3112121 | 0.70 | EGFR (0.72) | CSF1RHDAC1HDAC8HDAC6CASP1 | |
| SCHEMBL5135022 | 0.68 | ADORA2A (0.44) | EGFRNPC1RAB9ASMN1; SMN2ADORA2A | |
| SCHEMBL28872954 | 0.67 | ADORA2A (0.66) | EGFRKDRNPC1HTTRAB9A | |
| SCHEMBL18774826 | 0.67 | HTT (0.52) | EGFRKDRNPC1HTTRAB9A | |
| SCHEMBL5664944 | 0.65 | KDR (0.43) | EGFRKDR | |
| SCHEMBL5134739 | 0.63 | MAP4K4 (0.40) | NPC1HTTRAB9ASMN1; SMN2ADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080268460-A1 | Assays to Identify Irreversibly Binding Inhibitors of Receptor Tyrosine Kinases | WYETH (US) | 2008-10-30 | — | — | US | disclosed |