Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.45 |
| ▸ | MC4R | P32245 | 2/20 | 0.44 |
| ▸ | MC5R | P33032 | 2/20 | 0.44 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | MC3R | P41968 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 4/20 | 0.41 |
| ▸ | HTR7 | P34969 | 4/20 | 0.41 |
| ▸ | TACR1 | P25103 | 1/20 | 0.41 |
| ▸ | AGER | Q15109 | 3/20 | 0.40 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5137387 | 0.92 | MEN1 (0.57) | MEN1KMT2AALDH1A1KCNH2SLC6A2 | |
| SCHEMBL5136654 | 0.85 | MEN1 (0.49) | MEN1KMT2AALDH1A1KCNH2SLC6A2 | |
| SCHEMBL5138006 | 0.84 | ALDH1A1 (0.50) | MEN1KMT2AALDH1A1KCNH2SLC6A2 | |
| SCHEMBL5135771 | 0.84 | MEN1 (0.51) | MEN1KMT2AALDH1A1KCNH2SLC6A2 | |
| SCHEMBL5359589 | 0.84 | MEN1 (0.51) | MEN1KMT2AALDH1A1KCNH2SLC6A2 | |
| SCHEMBL5134903 | 0.82 | MTTP (0.50) | MEN1KMT2AALDH1A1LTB4R2TACR1 | |
| SCHEMBL5136027 | 0.81 | MEN1 (0.51) | MEN1KMT2AALDH1A1KCNH2SLC6A2 | |
| SCHEMBL6152464 | 0.81 | MEN1 (0.51) | MEN1KMT2AALDH1A1KCNH2SLC6A2 | |
| SCHEMBL5995268 | 0.81 | OPRM1 (0.48) | MEN1KMT2AALDH1A1KCNH2SLC6A2 | |
| SCHEMBL5137467 | 0.81 | KMT2A (0.48) | MEN1KMT2AALDH1A1KCNH2SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1490044-A4 | COMBINATION THERAPY FOR THE TREATMENT OF CONDITIONS WITH PATHOGENIC INFLAMMATORY COMPONENTS | NEUROGEN CORP (US) | 2008-04-16 | — | — | EP | disclosed |
| EP-1490044-A1 | COMBINATION THERAPY FOR THE TREATMENT OF CONDITIONS WITH PATHOGENIC INFLAMMATORY COMPONENTS | NEUROGEN CORPORATION (US) | 2004-12-29 | — | — | EP | disclosed |
| WO-2003084524-A1 | COMBINATION THERAPY FOR THE TREATMENT OF CONDITIONS WITH PATHOGENIC INFLAMMATORY COMPONENTS | NEUROGEN CORPORATION (US) | 2003-10-16 | — | — | WO | disclosed |