Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.50 |
| ▸ | MAPT | P10636 | 4/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | DHODH | Q02127 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 5/20 | 0.46 |
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.46 |
| ▸ | RELA | Q04206 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5136140 | 0.78 | SMN1; SMN2 (0.58) | SMN1; SMN2MAPTTP53ALDH1A1TSHR | |
| SCHEMBL27734018 | 0.70 | MAPT (0.53) | SMN1; SMN2MAPTTP53ALDH1A1HTT | |
| SCHEMBL8607458 | 0.70 | HTT (0.41) | SMN1; SMN2MAPTTP53ALDH1A1HTT | |
| SCHEMBL11831465 | 0.69 | MEN1 (0.64) | SMN1; SMN2MAPTTP53HTTP2RX3 | |
| SCHEMBL3582729 | 0.68 | NPC1 (0.73) | SMN1; SMN2MAPTTP53ALDH1A1LMNA | |
| SCHEMBL8458962 | 0.68 | KMT2A (0.45) | SMN1; SMN2MAPTTP53ALDH1A1TSHR | |
| SCHEMBL5196774 | 0.68 | NPC1 (0.56) | SMN1; SMN2MAPTALDH1A1HTTLMNA | |
| SCHEMBL5195674 | 0.68 | XDH (0.62) | SMN1; SMN2MAPTALDH1A1NPC1RAB9A | |
| SCHEMBL3584407 | 0.68 | SMN1; SMN2 (0.80) | SMN1; SMN2MAPTTP53ALDH1A1HTT | |
| SCHEMBL8970981 | 0.67 | PTK2 (0.70) | SMN1; SMN2MAPTTP53ALDH1A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1669068-B1 | Compounds effecting Glucokinase | ASTRAZENECA AB (SE) | 2008-06-11 | — | — | EP | disclosed |
| EP-1674097-B1 | Compounds effecting glucokinase | ASTRAZENECA AB (SE) | 2008-06-11 | — | — | EP | disclosed |
| EP-1661567-B1 | Compounds effecting Glucokinase | ASTRAZENECA AB (SE) | 2008-06-11 | — | — | EP | disclosed |