Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.58 |
| ▸ | TP53 | P04637 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | ADORA3 | P0DMS8 | 5/20 | 0.54 |
| ▸ | NPC1 | O15118 | 5/20 | 0.53 |
| ▸ | RAB9A | P51151 | 5/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | HTT | P42858 | 2/20 | 0.53 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.53 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.53 |
| ▸ | PKM | P14618 | 2/20 | 0.52 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.52 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3582729 | 0.78 | NPC1 (0.73) | SMN1; SMN2TP53MAPTALDH1A1LMNA | |
| SCHEMBL5136133 | 0.78 | SMN1; SMN2 (0.50) | SMN1; SMN2TP53MAPTALDH1A1LMNA | |
| SCHEMBL3584407 | 0.77 | SMN1; SMN2 (0.80) | SMN1; SMN2TP53MAPTALDH1A1LMNA | |
| SCHEMBL3584915 | 0.75 | ADORA3 (0.58) | SMN1; SMN2TP53MAPTALDH1A1LMNA | |
| SCHEMBL3584743 | 0.75 | ADORA3 (0.58) | SMN1; SMN2MAPTALDH1A1LMNAADORA3 | |
| SCHEMBL3587631 | 0.74 | ADORA3 (0.82) | SMN1; SMN2MAPTALDH1A1LMNAADORA3 | |
| SCHEMBL3580925 | 0.74 | KMT2A (0.78) | SMN1; SMN2MAPTALDH1A1LMNAADORA3 | |
| SCHEMBL14877171 | 0.73 | ALDH1A1 (0.75) | SMN1; SMN2TP53MAPTALDH1A1LMNA | |
| SCHEMBL2247099 | 0.73 | MAPT (1.00) | SMN1; SMN2TP53MAPTNPC1RAB9A | |
| SCHEMBL3586012 | 0.72 | ALDH1A1 (1.00) | SMN1; SMN2TP53ALDH1A1LMNANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1661567-B1 | Compounds effecting Glucokinase | ASTRAZENECA AB (SE) | 2008-06-11 | — | — | EP | disclosed |
| EP-1669068-B1 | Compounds effecting Glucokinase | ASTRAZENECA AB (SE) | 2008-06-11 | — | — | EP | disclosed |
| EP-1674097-B1 | Compounds effecting glucokinase | ASTRAZENECA AB (SE) | 2008-06-11 | — | — | EP | disclosed |