Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | RAD52 | P43351 | 1/20 | 0.35 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.35 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.34 |
| ▸ | PGR | P06401 | 1/20 | 0.34 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.34 |
| ▸ | AR | P10275 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | ATR | Q13535 | 1/20 | 0.32 |
| ▸ | MPO | P05164 | 1/20 | 0.32 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.32 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.31 |
| ▸ | PIM1 | P11309 | 1/20 | 0.31 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8571306 | 0.79 | PARP1 (0.46) | ABL1RAD52RIN1PIK3CGPARP1 | |
| SCHEMBL25958200 | 0.78 | ELANE (0.46) | ABL1RAD52RIN1PIK3CAPIK3CG | |
| SCHEMBL10444208 | 0.78 | ABL1 (0.37) | ABL1RAD52RIN1KDM4EALDH1A1 | |
| SCHEMBL21712343 | 0.76 | ABL1 (0.59) | ABL1RAD52RIN1KDM4EALDH1A1 | |
| SCHEMBL8727251 | 0.76 | ELANE (0.39) | ABL1RAD52RIN1KDM4EALDH1A1 | |
| SCHEMBL5505830 | 0.74 | PRMT5 (0.38) | KDM4EALDH1A1PIK3CAPIK3CGLMNA | |
| SCHEMBL3864343 | 0.73 | ADORA3 (0.41) | PIK3CG | |
| SCHEMBL1692289 | 0.73 | TLR7 (0.39) | ABL1RAD52RIN1LMNAPOLB | |
| SCHEMBL8727256 | 0.72 | TLR8 (0.40) | ABL1RAD52RIN1PIK3CAPIK3CG | |
| Hydrochloric Acid SCHEMBL8575045 | 0.72 | KCNH2 (0.32) | ABL1RAD52RIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1948173-A2 | HYDROXY AND ALKOXY SUBSTITUTED 1H-IMIDAZOQUINOLINES AND METHODS | Coley Pharmaceutical Group, Inc. (US) | 2008-07-30 | — | — | EP | disclosed |
| WO-2007056112-A2 | HYDROXY AND ALKOXY SUBSTITUTED 1H-IMIDAZOQUINOLINES AND METHODS | COLEY PHARMACEUTICAL GROUP, INC. (US) | 2007-05-18 | — | — | WO | disclosed |