Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 6/20 | 0.40 |
| ▸ | TLR7 | Q9NYK1 | 4/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | RAD52 | P43351 | 1/20 | 0.34 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.34 |
| ▸ | CDK1 | P06493 | 2/20 | 0.34 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.34 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.34 |
| ▸ | CDK2 | P24941 | 2/20 | 0.34 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.33 |
| ▸ | PIK3R1 | P27986 | 2/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.33 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.33 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.33 |
| ▸ | ELANE | P08246 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | HRH2 | P25021 | 1/20 | 0.33 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8727251 | 0.87 | ELANE (0.39) | TLR8TLR7ABL1RAD52RIN1 | |
| SCHEMBL6705148 | 0.80 | TLR8 (0.34) | TLR8TLR7PIK3CDPIK3R1PIK3CA | |
| SCHEMBL25958200 | 0.79 | ELANE (0.46) | TLR8TLR7ABL1RAD52RIN1 | |
| SCHEMBL1692289 | 0.79 | TLR7 (0.39) | TLR8TLR7ABL1RAD52RIN1 | |
| SCHEMBL5139045 | 0.78 | ABL1 (0.32) | ABL1RAD52RIN1 | |
| SCHEMBL8571306 | 0.77 | PARP1 (0.46) | ABL1RAD52RIN1PIK3CDPIK3CG | |
| SCHEMBL8575636 | 0.77 | TLR8 (0.35) | TLR8TLR7ABL1RAD52RIN1 | |
| SCHEMBL17956087 | 0.77 | TLR8 (0.31) | TLR8CDK1CCNB1CCNA2CDK2 | |
| SCHEMBL30612922 | 0.77 | TLR8 (0.49) | TLR8TLR7ABL1RAD52RIN1 | |
| SCHEMBL5139744 | 0.77 | ABL1 (0.31) | ABL1RAD52RIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5756747-A | 1H-imidazo 4,5-c!quinolin-4-amines | RIKER LABORATORIES, INC. (US) | 1998-05-26 | — | — | US | disclosed |
| EP-0385630-A2 | 1H-imidazo(4,5-c)Quinolin-4-amines as antivirals | RIKER LABORATORIES, INC. (US) | 1990-09-05 | — | — | EP | disclosed |