Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 2/20 | 0.49 |
| ▸ | MGLL | Q99685 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 2/20 | 0.43 |
| ▸ | PKM | P14618 | 2/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.43 |
| ▸ | CCR6 | P51684 | 1/20 | 0.43 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | CDC25B | P30305 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5303474 | 0.85 | ALDH1A1 (0.48) | AKR1C3MGLLALDH1A1L3MBTL1GAA | |
| SCHEMBL76714 | 0.84 | KMT2A (0.48) | MGLLALDH1A1L3MBTL1SMN1; SMN2ATM | |
| SCHEMBL19309377 | 0.83 | KMT2A (0.53) | MGLLALDH1A1SMN1; SMN2TDP1KMT2A | |
| SCHEMBL133554 | 0.83 | KMT2A (0.53) | MGLLALDH1A1SMN1; SMN2TDP1KMT2A | |
| SCHEMBL2053460 | 0.81 | ALDH1A1 (0.49) | AKR1C3ALDH1A1L3MBTL1NPSR1CYP1A2 | |
| SCHEMBL74375 | 0.81 | TSHR (0.49) | ALDH1A1L3MBTL1NPSR1SMN1; SMN2ATM | |
| SCHEMBL4806668 | 0.79 | ALDH1A1 (0.46) | ALDH1A1NPSR1GAASMN1; SMN2KMT2A | |
| SCHEMBL8540066 | 0.79 | TSHR (0.50) | ALDH1A1CYP3A4GAASMN1; SMN2TDP1 | |
| SCHEMBL15169078 | 0.78 | KMT2A (0.48) | MGLLCYP2C9SMN1; SMN2TDP1KMT2A | |
| SCHEMBL3403578 | 0.78 | ALDH1A1 (0.51) | MGLLALDH1A1L3MBTL1CYP3A4GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101437544-A | Chemically modified polycation polymer for siRNA delivery | ABBOTT LAB (US) | 2009-05-20 | — | — | CN | disclosed |
| EP-1981543-A1 | CHEMICALLY MODIFIED POLYCATION POLYMER FOR SIRNA DELIVERY | ABBOTT LABORATORIES (US) | 2008-10-22 | — | — | EP | disclosed |
| US-20080112916-A1 | CHEMICALLY MODIFIED POLYCATION POLYMER FOR siRNA DELIVERY | WAGNER ERNST | 2008-05-15 | — | — | US | disclosed |
| US-20070231392-A1 | CHEMICALLY MODIFIED POLYCATION POLYMER FOR siRNA DELIVERY | ABBOTT LABORATORIES | 2007-10-04 | — | — | US | disclosed |
| WO-2007084797-A1 | CHEMICALLY MODIFIED POLYCATION POLYMER FOR SIRNA DELIVERY | ABBOTT LABORATORIES (US) | 2007-07-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070231392-A1 | CHEMICALLY MODIFIED POLYCATION POLYMER FOR siRNA DELIVERY | PHAX, PCBP1, PUF60 | AKR1C3 4005/4885MGLL 4030/4885ALDH1A1 3701/4885 |
| US-20080112916-A1 | CHEMICALLY MODIFIED POLYCATION POLYMER FOR siRNA DELIVERY | PHAX, PCBP1, PUF60 | AKR1C3 4005/4885MGLL 4030/4885ALDH1A1 3701/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.