Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 3/20 | 0.41 |
| ▸ | CA1 | P00915 | 3/20 | 0.41 |
| ▸ | CA2 | P00918 | 3/20 | 0.41 |
| ▸ | CA9 | Q16790 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | AURKA | O14965 | 4/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.38 |
| ▸ | NR1D1 | P20393 | 1/20 | 0.37 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4309279 | 0.78 | APOBEC3G (0.45) | CA12CA1CA2CA9MAPT | |
| SCHEMBL4312071 | 0.76 | MEN1 (0.51) | CA12CA1CA2CA9MAPT | |
| SCHEMBL4313628 | 0.73 | ABCC8 (0.41) | CA12CA1CA2CA9MAPT | |
| SCHEMBL4325584 | 0.73 | MEN1 (0.44) | CA12CA1CA2CA9MAPT | |
| SCHEMBL1875303 | 0.73 | RAB9A (0.73) | MAPTRAB9ASMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL4313989 | 0.72 | MAPT (0.48) | CA12CA1CA2CA9MAPT | |
| SCHEMBL17055097 | 0.72 | LMNA (0.50) | MAPTKMT2ASMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL4311736 | 0.72 | MAPT (0.55) | MAPTMEN1KMT2ASMN1; SMN2LMNA | |
| SCHEMBL4316738 | 0.71 | AURKA (0.42) | CA12CA1CA2CA9MAPT | |
| SCHEMBL4319645 | 0.71 | MAPT (0.48) | CA12CA1CA2CA9MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1962830-A2 | AZAINDOLE INHIBITORS OF AURORA KINASES | SmithKline Beecham Corporation (US) | 2008-09-03 | — | — | EP | disclosed |
| WO-2007076348-A2 | AZAINDOLE INHIBITORS OF AURORA KINASES | SMITHKLINE BEECHAM CORPORATION (US) | 2007-07-05 | — | — | WO | disclosed |