⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18240979 | 0.64 | GPR119 (0.39) | — | |
| SCHEMBL18240978 | 0.58 | KDM1A (0.39) | — | |
| SCHEMBL31263344 | 0.57 | CHRM2 (0.41) | — | |
| SCHEMBL20235897 | 0.56 | SLC7A5 (0.32) | — | |
| SCHEMBL20235898 | 0.56 | SLC7A5 (0.32) | — | |
| SCHEMBL13190291 | 0.55 | CYP11B2 (0.41) | — | |
| SCHEMBL27647283 | 0.54 | USP2 (0.35) | — | |
| SCHEMBL20299301 | 0.53 | GAA (0.31) | — | |
| SCHEMBL20743059 | 0.53 | KDM4E (0.41) | — | |
| SCHEMBL26024957 | 0.52 | UCHL1 (0.37) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1898912-A1 | SYNERGISTIC MODULATION OF FLT3 KINASE USING A FLT3 INHIBITOR AND A FARNESYL TRANSFERASE INHIBITOR | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-03-19 | — | — | EP | disclosed |
| WO-2006138155-A1 | SYNERGISTIC MODULATION OF FLT3 KINASE USING A FLT3 INHIBITOR AND A FARNESYL TRANSFERASE INHIBITOR | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-12-28 | — | — | WO | disclosed |