Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.59 |
| ▸ | HPGD | P15428 | 3/20 | 0.59 |
| ▸ | MAPT | P10636 | 1/20 | 0.59 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.58 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 3/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.51 |
| ▸ | USP2 | O75604 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | PTGES | O14684 | 1/20 | 0.47 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.47 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.47 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5134630 | 0.98 | ALDH1A1 (0.62) | ALDH1A1HPGDMAPTGABRA1GABRB2 | |
| SCHEMBL4766559 | 0.88 | ALDH1A1 (0.55) | ALDH1A1HPGDMAPTGABRA1GABRB2 | |
| SCHEMBL5134793 | 0.83 | ALDH1A1 (0.55) | ALDH1A1HPGDMAPTGABRA1GABRB2 | |
| SCHEMBL5136528 | 0.82 | GABRA1 (0.46) | ALDH1A1HPGDMAPTGABRA1GABRB2 | |
| SCHEMBL14099478 | 0.82 | ALDH1A1 (0.64) | ALDH1A1HPGDMAPTSMN1; SMN2TSHR | |
| SCHEMBL4769015 | 0.79 | ALDH1A1 (0.55) | ALDH1A1HPGDMAPTSMN1; SMN2TSHR | |
| SCHEMBL5137429 | 0.79 | ALDH1A1 (0.44) | ALDH1A1HPGDMAPTGABRA1GABRB2 | |
| SCHEMBL5353976 | 0.78 | MEN1 (0.71) | ALDH1A1SMN1; SMN2TSHRMAPK1KMT2A | |
| SCHEMBL10107748 | 0.78 | HPGD (0.66) | ALDH1A1HPGDMAPTMAPK1LMNA | |
| SCHEMBL4766609 | 0.75 | ALDH1A1 (0.56) | ALDH1A1HPGDMAPTSMN1; SMN2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1490044-A4 | COMBINATION THERAPY FOR THE TREATMENT OF CONDITIONS WITH PATHOGENIC INFLAMMATORY COMPONENTS | NEUROGEN CORP (US) | 2008-04-16 | — | — | EP | disclosed |
| EP-1490044-A1 | COMBINATION THERAPY FOR THE TREATMENT OF CONDITIONS WITH PATHOGENIC INFLAMMATORY COMPONENTS | NEUROGEN CORPORATION (US) | 2004-12-29 | — | — | EP | disclosed |
| WO-2003084524-A1 | COMBINATION THERAPY FOR THE TREATMENT OF CONDITIONS WITH PATHOGENIC INFLAMMATORY COMPONENTS | NEUROGEN CORPORATION (US) | 2003-10-16 | — | — | WO | disclosed |