Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.64 |
| ▸ | HPGD | P15428 | 5/20 | 0.64 |
| ▸ | MAPT | P10636 | 2/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 5/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.51 |
| ▸ | USP2 | O75604 | 2/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5134630 | 0.85 | ALDH1A1 (0.62) | ALDH1A1HPGDMAPTSMN1; SMN2TSHR | |
| SCHEMBL5136876 | 0.82 | ALDH1A1 (0.59) | ALDH1A1HPGDMAPTSMN1; SMN2TSHR | |
| SCHEMBL4766609 | 0.79 | ALDH1A1 (0.56) | ALDH1A1HPGDMAPTSMN1; SMN2TSHR | |
| SCHEMBL4766559 | 0.78 | ALDH1A1 (0.55) | ALDH1A1HPGDMAPTSMN1; SMN2TSHR | |
| SCHEMBL5135859 | 0.78 | ALDH1A1 (0.55) | ALDH1A1HPGDMAPTSMN1; SMN2TSHR | |
| SCHEMBL14586259 | 0.76 | LMNA (0.54) | ALDH1A1HPGDLMNATRPM8NPC1 | |
| SCHEMBL5137552 | 0.76 | ALDH1A1 (0.52) | ALDH1A1HPGDMAPTSMN1; SMN2TSHR | |
| SCHEMBL5134793 | 0.76 | ALDH1A1 (0.55) | ALDH1A1HPGDMAPTSMN1; SMN2TSHR | |
| SCHEMBL1395310 | 0.74 | HPGD (0.69) | ALDH1A1HPGDTDP1MAPK1LMNA | |
| SCHEMBL4769015 | 0.73 | ALDH1A1 (0.55) | ALDH1A1HPGDMAPTSMN1; SMN2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1322309-B1 | HIGH AFFINITY SMALL MOLECULE C5A RECEPTOR MODULATORS | NEUROGEN CORP (US) | 2008-08-13 | — | — | EP | disclosed |
| US-7291621-B2 | Substituted biaryl amides C5a receptor modulators | NEUROGEN CORPORATION (US) | 2007-11-06 | — | — | US | disclosed |
| US-7291621-B2 | Substituted biaryl amides C5a receptor modulators | NEUROGEN CORPORATION (US) | 2007-11-06 | — | — | US | disclosed |
| US-7271270-B2 | High affinity small molecule C5a receptor modulators | NEUROGEN CORPORATION (US) | 2007-09-18 | — | — | US | disclosed |
| US-7271270-B2 | High affinity small molecule C5a receptor modulators | NEUROGEN CORPORATION (US) | 2007-09-18 | — | — | US | disclosed |