Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | AGER | Q15109 | 1/20 | 0.42 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | SLC6A12 | P48065 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5137978 | 0.91 | TSHR (0.51) | TSHRSMN1; SMN2NPC1KMT2AMAPT | |
| SCHEMBL5137304 | 0.82 | SMN1; SMN2 (0.41) | TSHRSMN1; SMN2NPC1TRPM8KMT2A | |
| SCHEMBL5135704 | 0.79 | KMT2A (0.45) | TSHRSMN1; SMN2KMT2AMAPTMEN1 | |
| SCHEMBL5135128 | 0.75 | AGER (0.44) | AGERKMT2AMEN1TDP1C5AR1 | |
| SCHEMBL5135222 | 0.75 | ALDH1A1 (0.46) | AGERMAPTLMNATDP1C5AR1 | |
| SCHEMBL5135379 | 0.75 | KMT2A (0.46) | TSHRSMN1; SMN2KMT2AMAPTMEN1 | |
| SCHEMBL5136534 | 0.73 | AGER (0.42) | AGERTRPM8TDP1C5AR1 | |
| SCHEMBL5357505 | 0.72 | OXTR (0.44) | TSHRSMN1; SMN2AGERKMT2AMAPT | |
| SCHEMBL5070014 | 0.72 | AGER (0.41) | AGERKMT2AMEN1C5AR1 | |
| SCHEMBL5137309 | 0.71 | ALDH1A1 (0.47) | TSHRSMN1; SMN2AGERMAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1490044-A4 | COMBINATION THERAPY FOR THE TREATMENT OF CONDITIONS WITH PATHOGENIC INFLAMMATORY COMPONENTS | NEUROGEN CORP (US) | 2008-04-16 | — | — | EP | disclosed |
| EP-1490044-A1 | COMBINATION THERAPY FOR THE TREATMENT OF CONDITIONS WITH PATHOGENIC INFLAMMATORY COMPONENTS | NEUROGEN CORPORATION (US) | 2004-12-29 | — | — | EP | disclosed |
| WO-2003084524-A1 | COMBINATION THERAPY FOR THE TREATMENT OF CONDITIONS WITH PATHOGENIC INFLAMMATORY COMPONENTS | NEUROGEN CORPORATION (US) | 2003-10-16 | — | — | WO | disclosed |