Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | GBA2 | Q9HCG7 | 1/20 | 0.38 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | BCHE | P06276 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 3/20 | 0.33 |
| ▸ | HRH2 | P25021 | 1/20 | 0.32 |
| ▸ | HRH1 | P35367 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL642245 | 0.84 | ATM (0.45) | ALDH1A1ATMKMT2AMEN1L3MBTL1 | |
| SCHEMBL9965481 | 0.84 | ATM (0.45) | ALDH1A1ATMKMT2AMEN1L3MBTL1 | |
| SCHEMBL31612903 | 0.83 | SMN1; SMN2 (0.42) | SMN1; SMN2LMNAPOLBGBA2PTGDR2 | |
| SCHEMBL22117681 | 0.83 | SMN1; SMN2 (0.42) | SMN1; SMN2LMNAPOLBGBA2PTGDR2 | |
| SCHEMBL1835614 | 0.83 | SMN1; SMN2 (0.42) | SMN1; SMN2LMNAPOLBGBA2PTGDR2 | |
| SCHEMBL3635011 | 0.81 | OPRK1 (0.33) | POLB | |
| SCHEMBL9965482 | 0.81 | ELANE (0.39) | POLBKMT2AMEN1TSHR | |
| SCHEMBL10174353 | 0.81 | ELANE (0.39) | POLBKMT2AMEN1TSHR | |
| SCHEMBL15112154 | 0.79 | SMN1; SMN2 (0.39) | SMN1; SMN2LMNAPOLBGBA2PTGDR2 | |
| SCHEMBL31753062 | 0.79 | LMNA (0.39) | SMN1; SMN2LMNAPOLBGBA2PTGDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1960347-A2 | 17-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 3 (17BETA-HSD3) INHIBITORS | Sterix Limited (GB) | 2008-08-27 | — | — | EP | disclosed |
| WO-2007003934-A2 | 17BETA-HYDR0XYSTER0ID DEHYDROGENASE TYPE 3 (17BETA-HSD3 ) INHIBITORS | STERIX LIMITED (GB) | 2007-01-11 | — | — | WO | disclosed |