Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.49 |
| ▸ | ESR1 | P03372 | 1/20 | 0.45 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.44 |
| ▸ | F10 | P00742 | 6/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.41 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.41 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.41 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.41 |
| ▸ | PLG | P00747 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30951857 | 0.87 | NR1H2 (0.53) | HRH3ESR1ESR2KMT2ATAAR1 | |
| SCHEMBL23701350 | 0.87 | CA1 (0.48) | HRH3KMT2AMEN1MAPTOPRM1 | |
| SCHEMBL30014279 | 0.87 | CA1 (0.48) | HRH3KMT2AMEN1MAPTOPRM1 | |
| SCHEMBL23709312 | 0.87 | NR1H2 (0.53) | HRH3ESR1ESR2KMT2ATAAR1 | |
| SCHEMBL28533346 | 0.84 | HRH3 (0.57) | HRH3ESR1ESR2KMT2ATAAR1 | |
| SCHEMBL23537968 | 0.84 | ESR1 (0.46) | HRH3ESR1ESR2KMT2ATAAR1 | |
| SCHEMBL5137232 | 0.81 | HRH3 (0.58) | HRH3KMT2AF10ABHD6 | |
| SCHEMBL31553208 | 0.80 | NR1H2 (0.46) | HRH3ESR1ESR2KMT2AMAPT | |
| SCHEMBL28539714 | 0.79 | ESR1 (0.52) | HRH3ESR1ESR2KMT2ATAAR1 | |
| SCHEMBL30290475 | 0.78 | HRH3 (0.52) | HRH3ESR1ESR2KMT2ATAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11992535-B2 | Compounds and probes for imaging huntingtin protein | CHDI FOUNDATION, INC. (US) | 2024-05-28 | — | — | US | disclosed |
| US-20210236663-A1 | COMPOUNDS AND PROBES FOR IMAGING HUNTINGTIN PROTEIN | CHDI FOUNDATION, INC. | 2021-08-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210236663-A1 | COMPOUNDS AND PROBES FOR IMAGING HUNTINGTIN PROTEIN | HTT, HYPK, HSPBP1 | HRH3 3299/4885ESR1 4197/4885ESR2 3214/4885 |
| US-11992535-B2 | Compounds and probes for imaging huntingtin protein | HTT, HYPK, HSPBP1 | HRH3 3299/4885ESR1 4197/4885ESR2 3214/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.