Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 7/20 | 0.51 |
| ▸ | THRB | P10828 | 7/20 | 0.51 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | ACP1 | P24666 | 1/20 | 0.33 |
| ▸ | CYSLTR2 | Q9NS75 | 2/20 | 0.33 |
| ▸ | CYSLTR1 | Q9Y271 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3141417 | 0.87 | THRA (0.51) | THRATHRBSCN9AHDAC1HDAC2 | |
| SCHEMBL3146203 | 0.82 | THRA (0.58) | THRATHRB | |
| SCHEMBL3133764 | 0.79 | THRA (0.54) | THRATHRBSCN9A | |
| SCHEMBL3140784 | 0.76 | THRA (0.55) | THRATHRBHDAC8HDAC6HDAC1 | |
| SCHEMBL3137511 | 0.74 | THRA (0.52) | THRATHRB | |
| SCHEMBL3141376 | 0.72 | THRB (0.50) | THRATHRBACP1 | |
| SCHEMBL3136298 | 0.70 | THRA (0.51) | THRATHRBHDAC1HDAC2 | |
| SCHEMBL3133322 | 0.69 | HDAC1 (0.37) | SCN9AHDAC8HDAC6HDAC1HDAC2 | |
| SCHEMBL3138766 | 0.69 | PDE2A (0.43) | THRATHRBHDAC8HDAC6HDAC1 | |
| SCHEMBL3140699 | 0.68 | THRA (0.54) | THRATHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899309-A1 | HETEROCYCLIC COMPOUNDS AS AGONISTS FOR THE THYROID RECEPTOR | KARO BIO AB (SE) | 2008-03-19 | — | — | EP | disclosed |
| WO-2007003419-A1 | HETEROCYCLIC COMPOUNDS AS AGONISTS FOR THE THYROID RECEPTOR | KARO BIO AB (SE) | 2007-01-11 | — | — | WO | disclosed |