Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 13/20 | 0.50 |
| ▸ | THRA | P10827 | 12/20 | 0.50 |
| ▸ | ACP1 | P24666 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3137713 | 0.88 | THRA (0.36) | THRBTHRA | |
| SCHEMBL5073545 | 0.84 | THRA (0.35) | THRBTHRA | |
| SCHEMBL3136329 | 0.83 | THRB (0.37) | THRBTHRA | |
| SCHEMBL3141256 | 0.76 | THRB (0.52) | THRBTHRAKCNH2 | |
| SCHEMBL3137690 | 0.75 | THRA (0.38) | THRBTHRA | |
| SCHEMBL3127279 | 0.74 | THRA (0.41) | THRBTHRA | |
| SCHEMBL3146203 | 0.74 | THRA (0.58) | THRBTHRAKCNH2 | |
| SCHEMBL3137511 | 0.73 | THRA (0.52) | THRBTHRA | |
| SCHEMBL3141417 | 0.72 | THRA (0.51) | THRBTHRAACP1 | |
| SCHEMBL5137461 | 0.72 | THRA (0.51) | THRBTHRAACP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100004271-A1 | HETEROCYCLIC COMPOUNDS AS AGANIST FOR THE THYROID RECEPTOR | KARO BIO AB (SE) | 2010-01-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100004271-A1 | HETEROCYCLIC COMPOUNDS AS AGANIST FOR THE THYROID RECEPTOR | TSHR, GHSR, TRHR | THRB 6/4885THRA 4/4885ACP1 1561/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.