Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 15/20 | 0.69 |
| ▸ | MAPK14 | Q16539 | 6/20 | 0.69 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.69 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.69 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.69 |
| ▸ | CSNK1D | P48730 | 3/20 | 0.55 |
| ▸ | JAK3 | P52333 | 1/20 | 0.51 |
| ▸ | ACVR1B | P36896 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5166006 | 0.84 | TGFBR1 (0.70) | TGFBR1MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL5503286 | 0.83 | TGFBR1 (0.74) | TGFBR1MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL373802 | 0.82 | TGFBR1 (1.00) | TGFBR1MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL4154047 | 0.76 | TGFBR1 (0.89) | TGFBR1MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL4084904 | 0.74 | TGFBR1 (0.84) | TGFBR1MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL13217778 | 0.73 | TGFBR1 (0.62) | TGFBR1MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL13217791 | 0.72 | TGFBR1 (0.60) | TGFBR1MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL13382571 | 0.72 | KDM4E (0.47) | TGFBR1MAPK14JAK3ACVR1BALDH1A1 | |
| SCHEMBL28825919 | 0.71 | TGFBR1 (0.82) | TGFBR1MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL13217617 | 0.70 | TGFBR1 (0.60) | TGFBR1MAPK14MAPK13MAPK12MAPK11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1804801-A2 | METHODS OF TREATING VASCULAR INJURIES | Biogen Idec MA, Inc. (US) | 2007-07-11 | — | — | EP | claimed |
| EP-1786802-A1 | PYRIMIDINYLIMIDAZOLES AS TGF-BETA INHIBITORS | Biogen Idec MA, Inc. (US) | 2007-05-23 | — | — | EP | claimed |
| WO-2006044509-A2 | METHODS OF TREATING VASCULAR INJURIES | BIOGEN IDEC MA INC. (US) | 2006-04-27 | — | — | WO | claimed |
| WO-2006026306-A1 | PYRIMIDINYLIMIDAZOLES AS TGF-BETA INHIBITORS | BIOGEN IDEC MA INC. (US) | 2006-03-09 | — | — | WO | claimed |
| WO-2008013928-A2 | TREATMENT OF CANCER WITH INTERFERON GENE DELIVERY IN COMBINATION WITH A TGF-BETA INHIBITOR | BIOGEN IDEC MA INC. (US) | 2008-01-31 | — | — | WO | disclosed |
| EP-1804801-A2 | METHODS OF TREATING VASCULAR INJURIES | Biogen Idec MA, Inc. (US) | 2007-07-11 | — | — | EP | disclosed |
| EP-1786802-A1 | PYRIMIDINYLIMIDAZOLES AS TGF-BETA INHIBITORS | Biogen Idec MA, Inc. (US) | 2007-05-23 | — | — | EP | disclosed |
| WO-2006044509-A2 | METHODS OF TREATING VASCULAR INJURIES | BIOGEN IDEC MA INC. (US) | 2006-04-27 | — | — | WO | disclosed |
| WO-2006026306-A1 | PYRIMIDINYLIMIDAZOLES AS TGF-BETA INHIBITORS | BIOGEN IDEC MA INC. (US) | 2006-03-09 | — | — | WO | disclosed |