Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 15/20 | 0.70 |
| ▸ | CSNK1D | P48730 | 4/20 | 0.70 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.70 |
| ▸ | CSNK1E | P49674 | 2/20 | 0.70 |
| ▸ | ACVR1B | P36896 | 2/20 | 0.70 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.70 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.70 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.70 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.70 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.70 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.70 |
| ▸ | MAPT | P10636 | 1/20 | 0.70 |
| ▸ | HPGD | P15428 | 1/20 | 0.70 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.70 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.70 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.70 |
| ▸ | RPS6KA1 | Q15418 | 1/20 | 0.70 |
| ▸ | CSNK1A1L | Q8N752 | 1/20 | 0.70 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5137950 | 0.84 | TGFBR1 (0.69) | TGFBR1CSNK1DCSNK1A1CSNK1EACVR1B | |
| SCHEMBL5497694 | 0.83 | TGFBR1 (0.75) | TGFBR1CSNK1DCSNK1A1CSNK1EACVR1B | |
| Sb-431542 SCHEMBL29381798 | 0.82 | TGFBR1 (1.00) | TGFBR1CSNK1DCSNK1A1CSNK1EACVR1B | |
| Sb-431542 SCHEMBL29359059 | 0.82 | TGFBR1 (1.00) | TGFBR1CSNK1DCSNK1A1CSNK1EACVR1B | |
| Sb-431542 SCHEMBL310028 | 0.82 | TGFBR1 (1.00) | TGFBR1CSNK1DCSNK1A1CSNK1EACVR1B | |
| Sb-431542 SCHEMBL2681356 | 0.81 | TGFBR1 (0.98) | TGFBR1CSNK1DCSNK1A1CSNK1EACVR1B | |
| Sb-431542 SCHEMBL29432843 | 0.81 | TGFBR1 (0.98) | TGFBR1CSNK1DCSNK1A1CSNK1EACVR1B | |
| Sb-431542 SCHEMBL155156 | 0.77 | TGFBR1 (0.85) | TGFBR1CSNK1DCSNK1A1CSNK1EACVR1B | |
| SCHEMBL373737 | 0.77 | TGFBR1 (1.00) | TGFBR1CSNK1DCSNK1A1CSNK1EACVR1B | |
| SCHEMBL29362480 | 0.77 | TGFBR1 (1.00) | TGFBR1CSNK1DCSNK1A1CSNK1EACVR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1804801-A2 | METHODS OF TREATING VASCULAR INJURIES | Biogen Idec MA, Inc. (US) | 2007-07-11 | — | — | EP | claimed |
| WO-2006044509-A2 | METHODS OF TREATING VASCULAR INJURIES | BIOGEN IDEC MA INC. (US) | 2006-04-27 | — | — | WO | claimed |
| WO-2008013928-A2 | TREATMENT OF CANCER WITH INTERFERON GENE DELIVERY IN COMBINATION WITH A TGF-BETA INHIBITOR | BIOGEN IDEC MA INC. (US) | 2008-01-31 | — | — | WO | disclosed |
| EP-1804801-A2 | METHODS OF TREATING VASCULAR INJURIES | Biogen Idec MA, Inc. (US) | 2007-07-11 | — | — | EP | disclosed |
| EP-1786802-A1 | PYRIMIDINYLIMIDAZOLES AS TGF-BETA INHIBITORS | Biogen Idec MA, Inc. (US) | 2007-05-23 | — | — | EP | disclosed |
| WO-2006044509-A2 | METHODS OF TREATING VASCULAR INJURIES | BIOGEN IDEC MA INC. (US) | 2006-04-27 | — | — | WO | disclosed |
| WO-2006026306-A1 | PYRIMIDINYLIMIDAZOLES AS TGF-BETA INHIBITORS | BIOGEN IDEC MA INC. (US) | 2006-03-09 | — | — | WO | disclosed |