Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.84 |
| ▸ | TP53 | P04637 | 4/20 | 0.84 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.84 |
| ▸ | CSNK2A2 | P19784 | 2/20 | 0.84 |
| ▸ | CSNK2B | P67870 | 2/20 | 0.84 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.84 |
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.81 |
| ▸ | CYP3A4 | P08684 | 8/20 | 0.81 |
| ▸ | HPGD | P15428 | 6/20 | 0.81 |
| ▸ | MEN1 | O00255 | 5/20 | 0.81 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.81 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.81 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.81 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.81 |
| ▸ | TSHR | P16473 | 3/20 | 0.81 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.81 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.81 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.81 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.62 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15676583 | 0.91 | KDM4E (0.74) | MAPTTP53SMN1; SMN2CSNK2A2CSNK2B | |
| SCHEMBL2121813 | 0.91 | KDM4E (0.74) | MAPTTP53SMN1; SMN2CSNK2A2CSNK2B | |
| SCHEMBL17786490 | 0.90 | MAPT (0.77) | MAPTTP53SMN1; SMN2CSNK2A2CSNK2B | |
| SCHEMBL30667386 | 0.90 | KDM4E (1.00) | MAPTTP53SMN1; SMN2CSNK2A2CSNK2B | |
| SCHEMBL5139273 | 0.90 | CYP3A4 (0.81) | MAPTTP53SMN1; SMN2CSNK2A2CSNK2B | |
| SCHEMBL4649962 | 0.90 | KDM4E (1.00) | MAPTTP53SMN1; SMN2CSNK2A2CSNK2B | |
| SCHEMBL4650608 | 0.88 | CSNK2A2 (0.82) | MAPTTP53SMN1; SMN2CSNK2A2CSNK2B | |
| SCHEMBL10037934 | 0.87 | MAPT (0.76) | MAPTTP53SMN1; SMN2CSNK2A2CSNK2B | |
| SCHEMBL10068185 | 0.87 | KDM4E (0.73) | MAPTTP53SMN1; SMN2CSNK2A2CSNK2B | |
| SCHEMBL7659274 | 0.86 | ADORA3 (0.81) | MAPTTP53SMN1; SMN2CSNK2A2CSNK2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007115181-A9 | COMPOUNDS EXHIBITING EFFLUX INHIBITOR ACTIVITY AND COMPOSITIONS AND USES THEREOF | EASTMAN CHEM CO (US) | 2008-04-03 | — | — | WO | disclosed |
| US-20070254859-A1 | Compounds exhibiting efflux inhibitor activity and composition and uses thereof | EASTMAN CHEMICAL COMPANY | 2007-11-01 | — | — | US | disclosed |
| WO-2007115181-A2 | COMPOUNDS EXHIBITING EFFLUX INHIBITOR ACTIVITY AND COMPOSITIONS AND USES THEREOF | EASTMAN CHEMICAL COMPANY (US) | 2007-10-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070254859-A1 | Compounds exhibiting efflux inhibitor activity and composition and uses thereof | ABCC4, NCOA4, NR4A3 | MAPT 4566/4885TP53 3361/4885SMN1; SMN2 3973/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.