SCHEMBL7659274

SCHEMBL7659274

COc1ccc2oc(-c3ccc(O)c(O)c3)c(O)c(=O)c2c1

nearest known ligand 0.81

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADORA3 P0DMS8 1/20 0.81
CSNK2A2 P19784 3/20 0.67
CSNK2B P67870 3/20 0.67
CSNK2A1 P68400 3/20 0.67
MAPT P10636 9/20 0.66
CYP3A4 P08684 9/20 0.66
KDM4E B2RXH2 9/20 0.66
MEN1 O00255 7/20 0.66
KMT2A Q03164 7/20 0.66
HSD17B10 Q99714 6/20 0.66
RECQL P46063 3/20 0.66
LMNA P02545 3/20 0.66
TDP1 Q9NUW8 2/20 0.66
APP P05067 2/20 0.66
THRB P10828 1/20 0.66
AKR1B1 P15121 1/20 0.66
ELAVL3 Q14576 1/20 0.66
IPMK Q8NFU5 1/20 0.66
IP6K2 Q9UHH9 1/20 0.66
TP53 P04637 6/20 0.64

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7652657 0.90 ADORA3 (1.00) ADORA3CSNK2A2CSNK2BCSNK2A1MAPT
SCHEMBL4650608 0.89 CSNK2A2 (0.82) ADORA3CSNK2A2CSNK2BCSNK2A1MAPT
SCHEMBL7124716 0.87 CSNK2A2 (0.74) ADORA3CSNK2A2CSNK2BCSNK2A1MAPT
SCHEMBL4648874 0.86 ABCG2 (0.82) ADORA3CSNK2A2CSNK2BCSNK2A1MAPT
SCHEMBL5138118 0.86 MAPT (0.84) ADORA3CSNK2A2CSNK2BCSNK2A1MAPT
SCHEMBL2121813 0.84 KDM4E (0.74) ADORA3CSNK2A2CSNK2BCSNK2A1MAPT
SCHEMBL15676583 0.84 KDM4E (0.74) ADORA3CSNK2A2CSNK2BCSNK2A1MAPT
SCHEMBL10067898 0.83 ADORA3 (0.71) ADORA3CSNK2A2CSNK2BCSNK2A1MAPT
SCHEMBL7659883 0.83 MAPT (0.71) ADORA3CSNK2A2CSNK2BCSNK2A1MAPT
SCHEMBL505584 0.82 MEN1 (0.79) ADORA3CSNK2A2CSNK2BCSNK2A1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1109800-A1 NOVEL CDK INHIBITORS HAVING FLAVONE STRUCTURE LG CHEMICAL LIMITED (KR) 2001-06-27 EP claimed
WO-2000012496-A1 NOVEL CDK INHIBITORS HAVING FLAVONE STRUCTURE LG CHEMICAL LTD. (KR) 2000-03-09 WO claimed
US-6500846-B1 2-(4-CHLOROPHENYL)-7-METHOXYCHROMEN-4-ONE, AS CYCLIN-DEPENDENT KINASE INHIBITORS, USED AS ANTICARCINOGENIC AGENTS OR FOR PROPHYLAXIS OF NEURODEGENERATIVE DISEASE LG CHEMICAL, LTD. (KR) 2002-12-31 US disclosed
EP-1109800-A1 NOVEL CDK INHIBITORS HAVING FLAVONE STRUCTURE LG CHEMICAL LIMITED (KR) 2001-06-27 EP disclosed
WO-2000012496-A1 NOVEL CDK INHIBITORS HAVING FLAVONE STRUCTURE LG CHEMICAL LTD. (KR) 2000-03-09 WO disclosed