Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.60 |
| ▸ | HTT | P42858 | 3/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 4/20 | 0.53 |
| ▸ | FDPS | P14324 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | APP | P05067 | 5/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | TTR | P02766 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28928137 | 0.90 | ALDH1A1 (0.60) | ALDH1A1SMN1; SMN2HTTMAPTNPC1 | |
| SCHEMBL3490042 | 0.89 | MAOB (0.57) | ALDH1A1SMN1; SMN2MAPTNPC1RAB9A | |
| SCHEMBL161066 | 0.89 | ALDH1A1 (0.73) | ALDH1A1SMN1; SMN2HTTMAPTNPC1 | |
| SCHEMBL6232167 | 0.85 | ALDH1A1 (0.65) | ALDH1A1SMN1; SMN2HTTMAPTNPC1 | |
| SCHEMBL9034724 | 0.84 | ALDH1A1 (0.61) | ALDH1A1SMN1; SMN2HTTMAPTNPC1 | |
| SCHEMBL752160 | 0.83 | ALDH1A1 (0.65) | ALDH1A1SMN1; SMN2HTTMAPTNPC1 | |
| SCHEMBL29377794 | 0.83 | ALDH1A1 (0.65) | ALDH1A1SMN1; SMN2HTTMAPTNPC1 | |
| SCHEMBL6766128 | 0.83 | MAOB (0.57) | ALDH1A1SMN1; SMN2HTTMAPTNPC1 | |
| SCHEMBL8698472 | 0.83 | ALDH1A1 (0.65) | ALDH1A1SMN1; SMN2HTTMAPTNPC1 | |
| SCHEMBL19658009 | 0.81 | FDPS (0.65) | ALDH1A1SMN1; SMN2HTTMAPTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1299381-B1 | SUBSTITUTED QUINAZOLINE DERIVATIVES AND THEIR USE AS INHIBITORS | ASTRAZENECA AB (SE) | 2008-05-07 | — | — | EP | disclosed |