Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GNAI3 | P08754 | 10/20 | 0.54 |
| ▸ | GNAO1 | P09471 | 10/20 | 0.54 |
| ▸ | GNAI1 | P63096 | 10/20 | 0.54 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
| ▸ | METAP1 | P53582 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7611083 | 0.83 | ALDH1A1 (0.46) | TSHRALDH1A1CYP3A4EPHX1HTT | |
| SCHEMBL15203118 | 0.83 | ALDH1A1 (0.57) | GNAI3GNAO1GNAI1TSHRALDH1A1 | |
| SCHEMBL25708221 | 0.82 | ALDH1A1 (0.44) | GNAI3GNAO1GNAI1TSHRALDH1A1 | |
| SCHEMBL20794221 | 0.80 | ALDH1A1 (0.53) | TSHRALDH1A1CYP3A4EPHX1GLA | |
| SCHEMBL2861071 | 0.78 | ALDH1A1 (0.52) | TSHRALDH1A1CYP3A4EPHX1HTT | |
| SCHEMBL22236675 | 0.75 | KDM4E (0.46) | GNAI3GNAO1GNAI1EPHX1SIGMAR1 | |
| SCHEMBL3265058 | 0.73 | GNAI3 (0.92) | GNAI3GNAO1GNAI1EPHX1KCNH2 | |
| SCHEMBL11592853 | 0.73 | ALDH1A1 (0.46) | TSHRALDH1A1CYP3A4EPHX1HTT | |
| SCHEMBL25143855 | 0.72 | METAP1 (0.36) | GNAI3GNAO1GNAI1TSHRALDH1A1 | |
| SCHEMBL18895985 | 0.72 | LMNA (0.37) | GNAI3GNAO1GNAI1TSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7320993-B1 | Aryl-substituted pyridylalkane, alkene, and alkine carboxamides useful as cytostatic useful as cytostatic and immuosuppressive agents | ASTELLAS DEUTSCHLAND GMBH (DE) | 2008-01-22 | — | — | US | disclosed |
| EP-1042291-B1 | ARYL-SUBSTITUTED PYRIDYLALKANE, ALKENE, AND ALKINE CARBOXAMIDES USEFUL AS CYTOSTATIC AND IMMUNOSUPPRESSIVE AGENTS | KLINGE CO CHEM PHARM FAB (DE) | 2005-07-13 | — | — | EP | disclosed |
| EP-1042291-A1 | ARYL-SUBSTITUTED PYRIDYLALKANE, ALKENE, AND ALKINE CARBOXAMIDES USEFUL AS CYTOSTATIC AND IMMUNOSUPPRESSIVE AGENTS | Klinge Pharma GmbH (DE) | 2000-10-11 | — | — | EP | disclosed |
| WO-1999031064-A1 | ARYL-SUBSTITUTED PYRIDYLALKANE, ALKENE, AND ALKINE CARBOXAMIDES USEFUL AS CYTOSTATIC AND IMMUNOSUPPRESSIVE AGENTS | KLINGE PHARMA GMBH (DE) | 1999-06-24 | — | — | WO | disclosed |