Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.38 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.36 |
| ▸ | GRM5 | P41594 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.33 |
| ▸ | MTOR | P42345 | 2/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6598196 | 0.82 | MAPT (0.51) | MAPTKCNJ1KDM4EALDH1A1GAA | |
| SCHEMBL6429584 | 0.80 | MAPT (0.48) | MAPTLMNAKDM4EALDH1A1GAA | |
| SCHEMBL2077222 | 0.77 | MAPT (0.51) | MAPTLMNAKCNJ1GRM5KDM4E | |
| SCHEMBL6595642 | 0.77 | KDM4E (0.51) | MAPTLMNALRRK2KDM4EALDH1A1 | |
| SCHEMBL2077223 | 0.77 | MAPT (0.55) | MAPTKDM4EALDH1A1HPGDTSHR | |
| SCHEMBL3453428 | 0.77 | MAPT (0.48) | MAPTKDM4EALDH1A1 | |
| SCHEMBL6702628 | 0.76 | KDM4E (0.59) | MAPTLMNAGRM5KDM4EALDH1A1 | |
| SCHEMBL13036137 | 0.75 | MAPT (0.49) | MAPTLMNAKDM4EALDH1A1GAA | |
| SCHEMBL10294621 | 0.73 | MAPT (0.51) | MAPTLMNAKDM4EALDH1A1GAA | |
| SCHEMBL19766581 | 0.73 | MAPT (0.51) | MAPTKCNJ1KDM4EALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2477981-A1 | HETEROCYCLIC MGLU5 ANTAGONISTS | Recordati Ireland Limited (IE) | 2012-07-25 | — | — | EP | disclosed |
| US-20120028931-A1 | HETEROCYCLIC M-GLU5 ANTAGONISTS | RECORDATI IRELAND LIMITED (IE) | 2012-02-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120028931-A1 | HETEROCYCLIC M-GLU5 ANTAGONISTS | OPRM1, GRM5, OPRD1 | MAPT 2573/4885LMNA 1601/4885LRRK2 490/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.