SCHEMBL5139147

SCHEMBL5139147

COc1ccc(Br)cc1CC(=O)N1CCC(c2nc(C(=O)N(C)C3CCCc4ccccc43)cs2)CC1

nearest known ligand 0.41

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.41
KDM4E B2RXH2 3/20 0.41
SMN1; SMN2 Q16637 1/20 0.37
XBP1 P17861 1/20 0.37
HTT P42858 1/20 0.37
CCR3 P51677 1/20 0.37
MEN1 O00255 2/20 0.36
KMT2A Q03164 2/20 0.36
CCR5 P51681 1/20 0.36
TDP1 Q9NUW8 1/20 0.36
SPR P35270 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2581301 0.92 KMT2A (0.39) ALDH1A1KDM4ESMN1; SMN2XBP1HTT
SCHEMBL2586402 0.91 KMT2A (0.42) ALDH1A1KDM4EXBP1HTTCCR3
SCHEMBL4789205 0.91 KMT2A (0.42) ALDH1A1KDM4EXBP1HTTCCR3
SCHEMBL778489 0.83 ALDH1A1 (0.39) ALDH1A1XBP1HTTMEN1KMT2A
SCHEMBL15049603 0.83 ALDH1A1 (0.39) ALDH1A1XBP1HTTMEN1KMT2A
SCHEMBL775883 0.83 HTT (0.41) ALDH1A1SMN1; SMN2XBP1HTTCCR3
SCHEMBL4759981 0.83 HTT (0.41) ALDH1A1SMN1; SMN2XBP1HTTCCR3
SCHEMBL2584875 0.80 ALDH1A1 (0.38) ALDH1A1SMN1; SMN2XBP1HTTMEN1
SCHEMBL2578184 0.79 SPR (0.40) ALDH1A1SMN1; SMN2XBP1HTTMEN1
SCHEMBL2578100 0.78 GPR119 (0.41) ALDH1A1XBP1HTTMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2008091594-A2 FUNGICIDAL MIXTURES E. I. DU PONT DE NEMOURS AND COMPANY (US) 2008-07-31 WO disclosed