Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 9/20 | 0.39 |
| ▸ | NAMPT | P43490 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 2/20 | 0.34 |
| ▸ | CLK2 | P49760 | 2/20 | 0.34 |
| ▸ | HIPK4 | Q8NE63 | 2/20 | 0.34 |
| ▸ | SRPK1 | Q96SB4 | 2/20 | 0.34 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.34 |
| ▸ | STK17A | Q9UEE5 | 2/20 | 0.34 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.34 |
| ▸ | NEK4 | P51957 | 1/20 | 0.34 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.34 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.34 |
| ▸ | MAP3K20 | Q9NYL2 | 1/20 | 0.34 |
| ▸ | MAP4K5 | Q9Y4K4 | 1/20 | 0.34 |
| ▸ | RXRA | P19793 | 3/20 | 0.33 |
| ▸ | PLK4 | O00444 | 1/20 | 0.33 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.33 |
| ▸ | CDK1 | P06493 | 1/20 | 0.33 |
| ▸ | RET | P07949 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL647759 | 0.86 | NPC1 (0.43) | BRD4KDRCLK2HIPK4SRPK1 | |
| SCHEMBL647637 | 0.80 | SMN1; SMN2 (0.44) | BRD4KDRCLK2HIPK4SRPK1 | |
| SCHEMBL646580 | 0.80 | DEGS1 (0.45) | DYRK1AALDH1A1ADORA3 | |
| SCHEMBL646895 | 0.79 | HPGDS (0.41) | RXRAALDH1A1 | |
| SCHEMBL646985 | 0.79 | DEGS1 (0.41) | BRD4RXRADYRK1AALDH1A1 | |
| SCHEMBL648016 | 0.78 | LIPE (0.43) | KDRCLK2HIPK4SRPK1CLK4 | |
| SCHEMBL646761 | 0.78 | ADORA3 (0.46) | BRD4KDRCLK2HIPK4SRPK1 | |
| SCHEMBL648071 | 0.78 | MAPT (0.44) | RXRAALDH1A1TSHRNPSR1PPARG | |
| SCHEMBL645596 | 0.77 | MEN1 (0.44) | ALDH1A1 | |
| SCHEMBL645754 | 0.77 | HPGDS (0.40) | BRD4KDRCLK2HIPK4SRPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2001476-A2 | BENZOIMIDAZOLYL-PARAZINE COMPOUNDS FOR INFLAMMATION AND IMMUNE-RELATED USES | Synta Pharmaceuticals Corporation (US) | 2008-12-17 | — | — | EP | claimed |
| WO-2007109362-A2 | BENZOIMIDAZOLYL-PARAZINE COMPOUNDS FOR INFLAMMATION AND IMMUNE-RELATED USES | SYNTA PHARMACEUTICALS CORP. (US) | 2007-09-27 | — | — | WO | claimed |