Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 3/20 | 0.51 |
| ▸ | PTGES | O14684 | 1/20 | 0.49 |
| ▸ | MME | P08473 | 1/20 | 0.48 |
| ▸ | ACE | P12821 | 1/20 | 0.48 |
| ▸ | CPA1 | P15085 | 1/20 | 0.48 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.48 |
| ▸ | CNR2 | P34972 | 2/20 | 0.47 |
| ▸ | PSMB5 | P28074 | 2/20 | 0.45 |
| ▸ | EPOR | P19235 | 1/20 | 0.45 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.45 |
| ▸ | CTSD | P07339 | 1/20 | 0.45 |
| ▸ | CCR8 | P51685 | 1/20 | 0.45 |
| ▸ | CETP | P11597 | 1/20 | 0.45 |
| ▸ | CTSS | P25774 | 1/20 | 0.44 |
| ▸ | CTSK | P43235 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21964974 | 0.92 | ALDH1A1 (0.51) | ALDH1A1LMNASMN1; SMN2POLBPTGES | |
| SCHEMBL3902883 | 0.90 | MME (0.56) | ALDH1A1LMNASMN1; SMN2POLBPTGES | |
| SCHEMBL6468835 | 0.82 | MME (0.48) | ALDH1A1LMNASMN1; SMN2POLBPTGES | |
| SCHEMBL4064892 | 0.81 | CTBP2 (0.54) | ALDH1A1POLB | |
| SCHEMBL5967075 | 0.79 | POLB (0.59) | ALDH1A1POLBCNR2PSMB5CTSS | |
| SCHEMBL27510864 | 0.79 | POLB (0.59) | ALDH1A1POLBCNR2PSMB5CTSS | |
| SCHEMBL7097974 | 0.78 | POLB (0.52) | ALDH1A1LMNAPOLBCNR2PSMB5 | |
| SCHEMBL8351647 | 0.77 | FFAR1 (0.60) | ALDH1A1POLBPTGESFFAR1CCR8 | |
| SCHEMBL6469284 | 0.77 | GAA (0.47) | ALDH1A1LMNASMN1; SMN2MMEACE | |
| SCHEMBL6469018 | 0.77 | FAAH (0.47) | ALDH1A1LMNASMN1; SMN2PTGESMME |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1654260-A4 | 6-MENBERED HETEROARYL COMPOUNDS FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS | PFIZER PROD INC (US) | 2008-09-24 | — | — | EP | disclosed |
| EP-1654260-A2 | 6-MENBERED HETEROARYL COMPOUNDS FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS | Pfizer Products Inc. (US) | 2006-05-10 | — | — | EP | disclosed |
| WO-2005011601-A2 | 6-MENBERED HETEROARYL COMPOUNDS FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS | PFIZER PRODUCTS, INC. (US) | 2005-02-10 | — | — | WO | disclosed |