Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 1/20 | 0.48 |
| ▸ | ACE | P12821 | 1/20 | 0.48 |
| ▸ | CPA1 | P15085 | 1/20 | 0.48 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | PSEN1 | P49768 | 4/20 | 0.45 |
| ▸ | PSEN2 | P49810 | 4/20 | 0.45 |
| ▸ | APH1B | Q8WW43 | 4/20 | 0.45 |
| ▸ | NCSTN | Q92542 | 4/20 | 0.45 |
| ▸ | APH1A | Q96BI3 | 4/20 | 0.45 |
| ▸ | PSENEN | Q9NZ42 | 4/20 | 0.45 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.44 |
| ▸ | PTGES | O14684 | 1/20 | 0.44 |
| ▸ | PSMB5 | P28074 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | CTSD | P07339 | 1/20 | 0.43 |
| ▸ | GPR132 | Q9UNW8 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6469284 | 0.86 | GAA (0.47) | MMEACECPA1ACE2ALDH1A1 | |
| SCHEMBL6469018 | 0.86 | FAAH (0.47) | MMEACECPA1ACE2ALDH1A1 | |
| SCHEMBL3902883 | 0.84 | MME (0.56) | MMEACECPA1ACE2ALDH1A1 | |
| SCHEMBL5139716 | 0.82 | ALDH1A1 (0.52) | MMEACECPA1ACE2ALDH1A1 | |
| SCHEMBL8258819 | 0.82 | PSEN1 (0.68) | ALDH1A1SMN1; SMN2PSEN1PSEN2APH1B | |
| SCHEMBL8258551 | 0.81 | CCNE1 (0.58) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL21964974 | 0.81 | ALDH1A1 (0.51) | MMEACECPA1ACE2ALDH1A1 | |
| SCHEMBL5047006 | 0.81 | S1PR1 (0.43) | MMEACECPA1ACE2ALDH1A1 | |
| SCHEMBL5041099 | 0.80 | S1PR1 (0.43) | MMEACECPA1ACE2ALDH1A1 | |
| SCHEMBL8258704 | 0.77 | PSEN1 (0.55) | ALDH1A1POLBPSEN1PSEN2APH1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050107381-A1 | 6-membered heteroaryl compounds for the treatment of neurodegenerative disorders | PFIZER, INC. | 2005-05-19 | — | — | US | claimed |
| US-20050107381-A1 | 6-membered heteroaryl compounds for the treatment of neurodegenerative disorders | PFIZER, INC. | 2005-05-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050107381-A1 | 6-membered heteroaryl compounds for the treatment of neurodegenerative disorders | APP, BACE1, SNCA | MME 282/4885ACE 1735/4885CPA1 2609/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.