Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 9/20 | 0.46 |
| ▸ | WEE2 | P0C1S8 | 2/20 | 0.44 |
| ▸ | WEE1 | P30291 | 2/20 | 0.44 |
| ▸ | PKMYT1 | Q99640 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | FYN | P06241 | 2/20 | 0.44 |
| ▸ | ABL1 | P00519 | 2/20 | 0.44 |
| ▸ | EGFR | P00533 | 2/20 | 0.44 |
| ▸ | SYK | P43405 | 2/20 | 0.44 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.44 |
| ▸ | STK25 | O00506 | 1/20 | 0.44 |
| ▸ | CIT | O14578 | 1/20 | 0.44 |
| ▸ | RIOK3 | O14730 | 1/20 | 0.44 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.44 |
| ▸ | CASK | O14936 | 1/20 | 0.44 |
| ▸ | GAK | O14976 | 1/20 | 0.44 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.44 |
| ▸ | MAP3K13 | O43283 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5025184 | 0.94 | SRC (0.50) | SRCWEE2WEE1PKMYT1ALDH1A1 | |
| SCHEMBL3280339 | 0.84 | CYP2D6 (0.56) | SRCALDH1A1KDM4EFYNABL1 | |
| SCHEMBL14421398 | 0.84 | CYP2D6 (0.56) | SRCALDH1A1KDM4EFYNABL1 | |
| SCHEMBL5027796 | 0.78 | EGFR (0.47) | ALDH1A1KDM4ETDP1EGFRSYK | |
| SCHEMBL4087889 | 0.78 | ALDH1A1 (0.51) | SRCWEE2WEE1PKMYT1ALDH1A1 | |
| SCHEMBL17375521 | 0.77 | SIRT6 (0.51) | ALDH1A1KDM4ETDP1EGFRSLC29A1 | |
| SCHEMBL5027787 | 0.77 | ABL1 (0.48) | SRCALDH1A1ABL1EGFRABL2 | |
| SCHEMBL2164504 | 0.77 | MAPT (0.41) | ALDH1A1KDM4ETDP1EGFRERBB2 | |
| SCHEMBL17922740 | 0.77 | ALDH1A1 (0.42) | ALDH1A1KDM4ETDP1CYP2D6L3MBTL1 | |
| SCHEMBL2163708 | 0.77 | ALDH1A1 (0.42) | ALDH1A1KDM4ETDP1CYP2D6L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1299381-B1 | SUBSTITUTED QUINAZOLINE DERIVATIVES AND THEIR USE AS INHIBITORS | ASTRAZENECA AB (SE) | 2008-05-07 | — | — | EP | disclosed |