Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.44 |
| ▸ | WEE2 | P0C1S8 | 2/20 | 0.44 |
| ▸ | WEE1 | P30291 | 2/20 | 0.44 |
| ▸ | PKMYT1 | Q99640 | 2/20 | 0.44 |
| ▸ | EGFR | P00533 | 3/20 | 0.43 |
| ▸ | KDR | P35968 | 2/20 | 0.43 |
| ▸ | CSF1R | P07333 | 3/20 | 0.43 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.43 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.43 |
| ▸ | STK25 | O00506 | 1/20 | 0.43 |
| ▸ | CIT | O14578 | 1/20 | 0.43 |
| ▸ | RIOK3 | O14730 | 1/20 | 0.43 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5025184 | 0.83 | SRC (0.50) | ALDH1A1KDM4ETDP1CYP2D6L3MBTL1 | |
| SCHEMBL17375521 | 0.82 | SIRT6 (0.51) | ALDH1A1KDM4ETDP1CYP2D6L3MBTL1 | |
| SCHEMBL23132944 | 0.80 | ALDH1A1 (0.56) | ALDH1A1KDM4ETDP1CYP2D6L3MBTL1 | |
| SCHEMBL13938553 | 0.80 | LMNA (0.47) | ALDH1A1KDM4ECYP2D6L3MBTL1CYP1A2 | |
| SCHEMBL27958219 | 0.80 | CYP2D6 (0.66) | ALDH1A1KDM4ETDP1CYP2D6CYP1A2 | |
| SCHEMBL12448363 | 0.79 | ALDH1A1 (0.58) | ALDH1A1KDM4ETDP1CYP2D6CYP1A2 | |
| SCHEMBL5105861 | 0.79 | ALDH1A1 (0.58) | ALDH1A1KDM4ETDP1CYP2D6CYP1A2 | |
| SCHEMBL5139995 | 0.78 | SRC (0.46) | ALDH1A1KDM4ETDP1CYP2D6L3MBTL1 | |
| SCHEMBL2209146 | 0.78 | SIRT6 (0.57) | ALDH1A1KDM4ETDP1CYP2D6CYP1A2 | |
| SCHEMBL20303961 | 0.78 | ALDH1A1 (0.53) | ALDH1A1KDM4ECYP2D6L3MBTL1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090029982-A1 | PROTEIN KINASE INHIBITORS | SUPERGEN, INC. (US) | 2009-01-29 | — | — | US | disclosed |
| US-20080207632-A1 | PROTEIN KINASE INHIBITORS | SUPERGEN, INC. (US) | 2008-08-28 | — | — | US | disclosed |
| WO-2008055233-A1 | PROTEIN KINASE INHIBITORS | SUPERGEN, INC. (US) | 2008-05-08 | — | — | WO | disclosed |
| EP-1888588-A2 | PROTEIN KINASE INHIBITORS | SuperGen, Inc. (US) | 2008-02-20 | — | — | EP | disclosed |
| WO-2006116733-A2 | PROTEIN KINASE INHIBITORS | SUPERGEN, INC. (US) | 2006-11-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080207632-A1 | PROTEIN KINASE INHIBITORS | ERBB3, ERBB2, AXL | ALDH1A1 3719/4885KDM4E 876/4885TDP1 970/4885 |
| US-20090029982-A1 | PROTEIN KINASE INHIBITORS | CDK2, PACSIN2, AKT1 | ALDH1A1 3578/4885KDM4E 962/4885TDP1 1039/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.