Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGM2 | P21980 | 8/20 | 0.60 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | ITGB3 | P05106 | 4/20 | 0.44 |
| ▸ | ITGAV | P06756 | 4/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5141370 | 1.00 | TGM2 (0.60) | TGM2MEN1KMT2AHTTLMNA | |
| SCHEMBL9825352 | 0.90 | TGM2 (0.68) | TGM2HTTLMNASMN1; SMN2 | |
| SCHEMBL4598758 | 0.89 | TGM2 (0.62) | TGM2HTTLMNASMN1; SMN2 | |
| SCHEMBL1091729 | 0.83 | TGM2 (0.65) | TGM2ITGB3ITGAVITGA2B | |
| SCHEMBL1091730 | 0.83 | TGM2 (0.65) | TGM2ITGB3ITGAVITGA2B | |
| SCHEMBL9825176 | 0.83 | TGM2 (0.65) | TGM2ITGB3ITGAVITGA2B | |
| SCHEMBL1091728 | 0.83 | TGM2 (0.65) | TGM2ITGB3ITGAVITGA2B | |
| SCHEMBL1092077 | 0.80 | TGM2 (0.67) | TGM2ITGB3ITGAVITGA2B | |
| SCHEMBL1092076 | 0.80 | TGM2 (0.67) | TGM2ITGB3ITGAVITGA2B | |
| SCHEMBL6004049 | 0.80 | TGM2 (0.64) | TGM2ITGB3ITGAVITGA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1931205-A2 | TRANSGLUTAMINASE INHIBITORS AND METHODS OF USE THEREOF | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2008-06-18 | — | — | EP | disclosed |
| WO-2007025247-A2 | TRANSGLUTAMINASE INHIBITORS AND METHODS OF USE THEREOF | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2007-03-01 | — | — | WO | disclosed |
| EP-1706129-A1 | DRUG THERAPY FOR CELIAC SPRUE | The Board of Trustees of The Leland Stanford Junior University (US) | 2006-10-04 | — | — | EP | disclosed |
| WO-2005049064-A1 | DRUG THERAPY FOR CELIAC SPRUE | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2005-06-02 | — | — | WO | disclosed |