Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGM2 | P21980 | 10/20 | 0.68 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4598758 | 0.92 | TGM2 (0.62) | TGM2LMNASMN1; SMN2HTTALDH1A1 | |
| SCHEMBL5141369 | 0.90 | TGM2 (0.60) | TGM2LMNASMN1; SMN2HTT | |
| SCHEMBL5141370 | 0.90 | TGM2 (0.60) | TGM2LMNASMN1; SMN2HTT | |
| SCHEMBL9825601 | 0.86 | TGM2 (0.53) | TGM2LMNASMN1; SMN2CYP1A2HTT | |
| SCHEMBL6004049 | 0.86 | TGM2 (0.64) | TGM2CYP1A2 | |
| SCHEMBL1103747 | 0.86 | TGM2 (0.72) | TGM2CYP1A2 | |
| SCHEMBL1091898 | 0.86 | TGM2 (0.72) | TGM2CYP1A2 | |
| SCHEMBL1091900 | 0.86 | TGM2 (0.72) | TGM2CYP1A2 | |
| SCHEMBL9825944 | 0.86 | TGM2 (0.56) | TGM2LMNASMN1; SMN2CYP1A2ALDH1A1 | |
| SCHEMBL1367897 | 0.85 | TGM2 (0.63) | TGM2LMNASMN1; SMN2CYP1A2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0237082-B1 | 3,5-DISUBSTITUTED 4,5-DIHYDROISOXAZOLES AS TRANSGLUTAMINASE INHIBITORS | SYNTEX (U.S.A.) INC. (US) | 1991-05-29 | — | — | EP | claimed |
| EP-0237082-A2 | 3,5-disubstituted 4,5-dihydroisoxazoles as transglutaminase inhibitors | SYNTEX (U.S.A.) INC. (US) | 1987-09-16 | — | — | EP | claimed |
| EP-0237082-B1 | 3,5-DISUBSTITUTED 4,5-DIHYDROISOXAZOLES AS TRANSGLUTAMINASE INHIBITORS | SYNTEX (U.S.A.) INC. (US) | 1991-05-29 | — | — | EP | disclosed |
| US-4929630-A | SKIN DISORDERS, ACNE, 4,5-DIHYDROISOOXAZOLE PEPTIDES | SYNTEX (U.S.A.) INC. (US) | 1990-05-29 | — | — | US | disclosed |
| US-4912120-A | Containing amine and amide substitution | SYNTEX (U.S.A.) INC. (US) | 1990-03-27 | — | — | US | disclosed |
| EP-0237082-A2 | 3,5-disubstituted 4,5-dihydroisoxazoles as transglutaminase inhibitors | SYNTEX (U.S.A.) INC. (US) | 1987-09-16 | — | — | EP | disclosed |