Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 4/20 | 0.40 |
| ▸ | DHODH | Q02127 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | DHFR | P00374 | 1/20 | 0.39 |
| ▸ | TNKS | O95271 | 1/20 | 0.38 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.38 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.38 |
| ▸ | MAPK13 | O15264 | 3/20 | 0.37 |
| ▸ | RAF1 | P04049 | 3/20 | 0.37 |
| ▸ | MAPK12 | P53778 | 3/20 | 0.37 |
| ▸ | MAPK11 | Q15759 | 3/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.37 |
| ▸ | BRAF | P15056 | 2/20 | 0.37 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22476352 | 0.92 | PARP1 (0.46) | PARP1DHODHMAPTMEN1ALDH1A1 | |
| SCHEMBL27761918 | 0.77 | PARP1 (0.43) | PARP1DHODHMAPTMEN1ALDH1A1 | |
| SCHEMBL24500765 | 0.76 | DHODH (0.43) | PARP1DHODHMAPTMEN1ALDH1A1 | |
| SCHEMBL27886638 | 0.76 | ALDH1A1 (0.47) | PARP1MAPTMEN1ALDH1A1HPGD | |
| SCHEMBL27761915 | 0.75 | PARP1 (0.44) | PARP1DHODHMAPTMEN1ALDH1A1 | |
| SCHEMBL22587488 | 0.75 | ADORA2A (0.46) | MAPTMEN1ALDH1A1HPGDKMT2A | |
| SCHEMBL783767 | 0.75 | PI4KA (0.50) | PARP1DHODHMAPTMEN1ALDH1A1 | |
| SCHEMBL25637936 | 0.68 | RHEB (0.48) | PARP1ALDH1A1MAPK13RAF1MAPK12 | |
| SCHEMBL30440652 | 0.68 | RHEB (0.48) | PARP1ALDH1A1MAPK13RAF1MAPK12 | |
| SCHEMBL17060210 | 0.68 | FGFR1 (0.59) | PARP1MAPTMEN1ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2008210-A1 | MODULATION OF PHOSPHORYL TRANSFERASE ACTIVITY OF GLUTAMINE SYNTHETASE | CSIR (ZA) | 2008-12-31 | — | — | EP | disclosed |
| WO-2007105023-A1 | MODULATION OF PHOSPHORYL TRANSFERASE ACTIVITY OF GLUTAMINE SYNTHETASE | CSIR (ZA) | 2007-09-20 | — | — | WO | disclosed |