⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23130115 | 0.81 | DGKA (0.32) | — | |
| SCHEMBL1100417 | 0.79 | — | — | |
| SCHEMBL7358624 | 0.78 | CYP1A2 (0.45) | — | |
| SCHEMBL21891775 | 0.77 | ADRA2A (0.32) | — | |
| SCHEMBL18828861 | 0.77 | TSHR (0.36) | — | |
| SCHEMBL23709967 | 0.76 | — | — | |
| SCHEMBL70685 | 0.76 | — | — | |
| SCHEMBL23129743 | 0.76 | MAPK1 (0.31) | — | |
| SCHEMBL10836027 | 0.76 | NLRP3 (0.46) | — | |
| Hydrochloric Acid SCHEMBL25408509 | 0.74 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210238141-A1 | COMPOUND, CURING AGENT COMPOSITION, RESIN COMPOSITION, COATING COMPOSITION AND RESIN CURED PRODUCT | ASAHI KASEI KABUSHIKI KAISHA (JP) | 2021-08-05 | — | — | US | disclosed |
| EP-2099845-B1 | MULTI-FUNCTIONAL POLYALKYLENE OXIDES, HYDROGELS AND TISSUE ADHESIVES | ACTAMAX SURGICAL MAT LLC (US) | 2020-12-23 | — | — | EP | disclosed |
| US-20160326125-A1 | SULFONE AMIDE LINKED BENZOTHIAZOLE INHIBITORS OF ENDOTHELIAL LIPASE | BRISTOL MYERS SQUIBB CO (US) | 2016-11-10 | — | — | US | disclosed |
| US-9487517-B2 | Spiroimidazolone derivative | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2016-11-08 | — | — | US | disclosed |
| US-20160016956-A1 | SPIROIMIDAZOLONE DERIVATIVE | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2016-01-21 | — | — | US | disclosed |
| US-9169254-B2 | Spiroimidazolone derivative | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2015-10-27 | — | — | US | disclosed |
| US-8895582-B2 | Certain chemical entities, compositions, and methods | CYTOKINETICS, INC. (US) | 2014-11-25 | — | — | US | disclosed |
| US-8759374-B2 | Certain chemical entities, compositions, and methods | CYTOKINETICS, INC. (US) | 2014-06-24 | — | — | US | disclosed |
| US-20130053348-A1 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | QIAN XIANGPING (US) | 2013-02-28 | — | — | US | disclosed |
| US-20120270838-A1 | SPIROIMIDAZOLONE DERIVATIVE | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2012-10-25 | — | — | US | disclosed |
| EP-1813616-A2 | Pyrazoloquinolines with immunomodulating activity | Active Biotech AB (SE) | 2007-08-01 | — | — | EP | disclosed |
| EP-1562944-B1 | PYRAZOLOQUINOLINES WITH IMMUNOMODULATING ACTIVITY | ACTIVE BIOTECH AB (SE) | 2007-02-14 | — | — | EP | disclosed |
| US-20060217411-A1 | Immunomodulatory compounds | ACTIVE BIOTECH AB | 2006-09-28 | — | — | US | disclosed |
| US-7081456-B2 | Immunomodulatory compounds | ACTIVE BIOTECH AB (SE) | 2006-07-25 | — | — | US | disclosed |
| US-20050203118-A9 | Immunomodulatory compounds | ACTIVE BIOTECH AB (SE) | 2005-09-15 | — | — | US | disclosed |
| EP-1562944-A1 | PYRAZOLOQUINOLINES WITH IMMUNOMODULATING ACTIVITY | Active Biotech AB (SE) | 2005-08-17 | — | — | EP | disclosed |
| US-20040116461-A1 | Immunomodulatory compounds | ACTIVE BIOTECH AB (SE) | 2004-06-17 | — | — | US | disclosed |
| WO-2004048378-A1 | PYRAZOLOQUINOLINES WITH IMMUNOMODULATING ACTIVITY | ACTIVE BIOTECH AB (SE) | 2004-06-10 | — | — | WO | disclosed |
| US-4452798-A | 1-Substituted phenyl-4-alkyl hydantoin piperazine compounds as antihypertensive agents | WARNER-LAMBERT COMPANY (US) | 1984-06-05 | — | — | US | disclosed |
| EP-0103357-A2 | Substituted phenylpiperazine compounds suitable as antihypertensive agents, and processes for their production | WARNER-LAMBERT COMPANY (US) | 1984-03-21 | — | — | EP | disclosed |