Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | FGB | P02675 | 1/20 | 0.46 |
| ▸ | MAP2K7 | O14733 | 2/20 | 0.45 |
| ▸ | CDC25A | P30304 | 2/20 | 0.45 |
| ▸ | CDC25B | P30305 | 2/20 | 0.45 |
| ▸ | PRNP | P04156 | 2/20 | 0.45 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.45 |
| ▸ | S100A4 | P26447 | 1/20 | 0.44 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.43 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29514990 | 1.00 | ALDH1A1 (0.49) | ALDH1A1CYP2C19POLBMEN1KMT2A | |
| SCHEMBL4272055 | 0.89 | ALDH1A1 (0.61) | ALDH1A1POLBMEN1KMT2ARXFP1 | |
| SCHEMBL4276237 | 0.86 | PTGS2 (0.59) | ALDH1A1POLBNPSR1RXFP1CYSLTR2 | |
| SCHEMBL4273989 | 0.81 | CYP1A2 (0.61) | ALDH1A1POLBMEN1KMT2ACDC25B | |
| SCHEMBL9701297 | 0.79 | MEN1 (0.54) | ALDH1A1CYP2C19POLBMEN1KMT2A | |
| SCHEMBL14053505 | 0.79 | ALDH1A1 (0.43) | ALDH1A1POLBMEN1KMT2AFGB | |
| SCHEMBL13125 | 0.78 | ALDH1A1 (0.49) | ALDH1A1CYP2C19POLBMEN1KMT2A | |
| SCHEMBL14557238 | 0.78 | MAP2K7 (0.49) | ALDH1A1CYP2C19POLBMEN1KMT2A | |
| SCHEMBL21189320 | 0.78 | CYP1A2 (0.68) | ALDH1A1CYP2C19POLBSMN1; SMN2TSHR | |
| SCHEMBL5637483 | 0.78 | SMN1; SMN2 (0.56) | ALDH1A1CYP2C19POLBMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230234962-A1 | OXA-AZASPIRO DERIVATIVE, AND PREPARATION METHOD THEREFOR AND PHARMACEUTICAL USE THEREOF | JIANGSU HENGRUI PHARMACEUTICALS CO., LTD. (CN) | 2023-07-27 | — | — | US | disclosed |
| US-20230234962-A1 | OXA-AZASPIRO DERIVATIVE, AND PREPARATION METHOD THEREFOR AND PHARMACEUTICAL USE THEREOF | JIANGSU HENGRUI PHARMACEUTICALS CO., LTD. (CN) | 2023-07-27 | — | — | US | disclosed |
| US-20230234962-A1 | OXA-AZASPIRO DERIVATIVE, AND PREPARATION METHOD THEREFOR AND PHARMACEUTICAL USE THEREOF | JIANGSU HENGRUI PHARMACEUTICALS CO., LTD. (CN) | 2023-07-27 | — | — | US | disclosed |
| EP-4190789-A1 | OXA-AZASPIRO DERIVATIVE, AND PREPARATION METHOD THEREFOR AND PHARMACEUTICAL USE THEREOF | Jiangsu Hengrui Pharmaceuticals Co., Ltd. (CN) | 2023-06-07 | — | — | EP | disclosed |
| CN-115836077-A | Oxaazaspiro derivatives, preparation method and medical application thereof | 江苏恒瑞医药股份有限公司 | 2023-03-21 | — | — | CN | disclosed |
| US-7291612-B2 | Immunomodulatory compounds | ACTIVE BIOTECH A.B. (SE) | 2007-11-06 | — | — | US | disclosed |
| US-7291612-B2 | Immunomodulatory compounds | ACTIVE BIOTECH A.B. (SE) | 2007-11-06 | — | — | US | disclosed |
| US-7291612-B2 | Immunomodulatory compounds | ACTIVE BIOTECH A.B. (SE) | 2007-11-06 | — | — | US | disclosed |
| EP-1813616-A2 | Pyrazoloquinolines with immunomodulating activity | Active Biotech AB (SE) | 2007-08-01 | — | — | EP | disclosed |
| EP-1813616-A2 | Pyrazoloquinolines with immunomodulating activity | Active Biotech AB (SE) | 2007-08-01 | — | — | EP | disclosed |
| EP-1562944-B1 | PYRAZOLOQUINOLINES WITH IMMUNOMODULATING ACTIVITY | ACTIVE BIOTECH AB (SE) | 2007-02-14 | — | — | EP | disclosed |
| EP-1562944-B1 | PYRAZOLOQUINOLINES WITH IMMUNOMODULATING ACTIVITY | ACTIVE BIOTECH AB (SE) | 2007-02-14 | — | — | EP | disclosed |
| US-20060217411-A1 | Immunomodulatory compounds | ACTIVE BIOTECH AB | 2006-09-28 | — | — | US | disclosed |
| US-7081456-B2 | Immunomodulatory compounds | ACTIVE BIOTECH AB (SE) | 2006-07-25 | — | — | US | disclosed |
| US-20050203118-A9 | Immunomodulatory compounds | ACTIVE BIOTECH AB (SE) | 2005-09-15 | — | — | US | disclosed |
| EP-1562944-A1 | PYRAZOLOQUINOLINES WITH IMMUNOMODULATING ACTIVITY | Active Biotech AB (SE) | 2005-08-17 | — | — | EP | disclosed |
| US-20040116461-A1 | Immunomodulatory compounds | ACTIVE BIOTECH AB (SE) | 2004-06-17 | — | — | US | disclosed |
| WO-2004048378-A1 | PYRAZOLOQUINOLINES WITH IMMUNOMODULATING ACTIVITY | ACTIVE BIOTECH AB (SE) | 2004-06-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050203118-A9 | Immunomodulatory compounds | CD40, ICOS, CD40LG | ALDH1A1 3341/4885CYP2C19 3468/4885POLB 4509/4885 |
| US-20230234962-A1 | OXA-AZASPIRO DERIVATIVE, AND PREPARATION METHOD THEREFOR AND PHARMACEUTICAL USE THEREOF | PIK3CD, PIK3CA, PIK3R5 | ALDH1A1 704/4885CYP2C19 129/4885POLB 694/4885 |
| US-20060217411-A1 | Immunomodulatory compounds | CD40, ICOS, CD40LG | ALDH1A1 3341/4885CYP2C19 3468/4885POLB 4509/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.