Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | GLRA1 | P23415 | 1/20 | 0.49 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.48 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.46 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.46 |
| ▸ | SGMS2 | Q8NHU3 | 2/20 | 0.46 |
| ▸ | THRA | P10827 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.44 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.44 |
| ▸ | CLCN2 | P51788 | 1/20 | 0.44 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16789583 | 0.92 | GLRA1 (0.55) | L3MBTL1MAPTCYP2C9CYP2C19SMN1; SMN2 | |
| SCHEMBL11112757 | 0.88 | CHRM4 (0.48) | L3MBTL1MAPTCYP2C9CYP2C19SMN1; SMN2 | |
| SCHEMBL6476026 | 0.88 | SGMS2 (0.52) | L3MBTL1MAPTSMN1; SMN2TDP1GLRA1 | |
| SCHEMBL2229263 | 0.87 | FOLH1 (0.57) | L3MBTL1MAPTCYP2C9CYP2C19SMN1; SMN2 | |
| SCHEMBL28361495 | 0.87 | MAPT (0.57) | L3MBTL1MAPTCYP2C9CYP2C19SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL514324 | 0.86 | FOLH1 (0.56) | L3MBTL1MAPTCYP2C9CYP2C19SMN1; SMN2 | |
| SCHEMBL30184648 | 0.84 | PARP1 (0.54) | L3MBTL1MAPTCYP2C9CYP2C19SMN1; SMN2 | |
| SCHEMBL26021326 | 0.84 | MAPT (0.65) | L3MBTL1MAPTCYP2C9CYP2C19SMN1; SMN2 | |
| SCHEMBL9336507 | 0.83 | MAPT (0.63) | L3MBTL1MAPTCYP2C9CYP2C19SMN1; SMN2 | |
| SCHEMBL18499402 | 0.83 | ALDH1A1 (0.55) | L3MBTL1MAPTCYP2C9CYP2C19SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9399631-B2 | Polyphenol proteasome inhibitors, synthesis, and methods of use | UNIVERSITY OF SOUTH FLORIDA (US) | 2016-07-26 | — | — | US | disclosed |
| US-20140045931-A1 | POLYPHENOL PROTEASOME INHIBITORS, SYNTHESIS, AND METHODS OF USE | THE HONG KONG POLYTECHNIC UNIVERSITY (HK) | 2014-02-13 | — | — | US | disclosed |
| US-8563607-B2 | Polyphenol proteasome inhibitors, synthesis, and methods of use | UNIVERSITY OF SOUTH FLORIDA (US) | 2013-10-22 | — | — | US | disclosed |
| US-20120029067-A1 | Polyphenol Proteasome Inhibitors, Synthesis, and Methods of Use | UNIVERSITY OF SOUTH FLORIDA (US) | 2012-02-02 | — | — | US | disclosed |
| US-8058310-B2 | Polyphenol proteasome inhibitors, synthesis, and methods of use | UNIVERSITY OF SOUTH FLORIDA (US) | 2011-11-15 | — | — | US | disclosed |
| US-7767711-B2 | Polyphenol proteasome inhibitors, synthesis, and methods of use | UNIVERSITY OF SOUTH FLORIDA (US) | 2010-08-03 | — | — | US | disclosed |
| US-20100173985-A1 | Polyphenol proteasome inhibitors, synthesis, and methods of use | UNIVERSITY OF SOUTH FLORIDA (US) | 2010-07-08 | — | — | US | disclosed |
| US-7358383-B2 | Polyphenol proteasome inhibitors, synthesis, and methods of use | UNIVERSITY OF SOUTH FLORIDA (US) | 2008-04-15 | — | — | US | disclosed |
| US-20080015248-A1 | Polyphenol proteasome inhibitors, synthesis, and methods of use | DOU Q P | 2008-01-17 | — | — | US | disclosed |
| US-20040186167-A1 | Polyphenol proteasome inhibitors, synthesis, and methods of use | THE HONG KONG POLYTECHNIC UNIVERSITY (CN) | 2004-09-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140045931-A1 | POLYPHENOL PROTEASOME INHIBITORS, SYNTHESIS, AND METHODS OF USE | PSMC1, PSMB5, PSMC5 | L3MBTL1 3328/4885MAPT 481/4885CYP2C9 3770/4885 |
| US-20080015248-A1 | Polyphenol proteasome inhibitors, synthesis, and methods of use | PSMC1, PSMB5, PSMC5 | L3MBTL1 3328/4885MAPT 481/4885CYP2C9 3770/4885 |
| US-20100173985-A1 | Polyphenol proteasome inhibitors, synthesis, and methods of use | PSMC1, PSMB5, PSMC5 | L3MBTL1 3328/4885MAPT 481/4885CYP2C9 3770/4885 |
| US-20120029067-A1 | Polyphenol Proteasome Inhibitors, Synthesis, and Methods of Use | PSMC1, PSMB5, PSMC5 | L3MBTL1 3328/4885MAPT 481/4885CYP2C9 3770/4885 |
| US-20040186167-A1 | Polyphenol proteasome inhibitors, synthesis, and methods of use | PSMC1, PSMB5, PSMC5 | L3MBTL1 3328/4885MAPT 481/4885CYP2C9 3770/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.