Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Probucol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPN | P05981 | 1/20 | 1.00 |
| ▸ | MAPT | P10636 | 1/20 | 1.00 |
| ▸ | ALOX15 | P16050 | 1/20 | 1.00 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 1.00 |
| ▸ | VCAM1 | P19320 | 13/20 | 0.60 |
| ▸ | CA2 | P00918 | 4/20 | 0.58 |
| ▸ | CA1 | P00915 | 2/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | TYR | P14679 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | GALR3 | O60755 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Probucol SCHEMBL4150 | 1.00 | HPN (1.00) | HPNMAPTALOX15SIRT5VCAM1 | |
| Probucol SCHEMBL8344652 | 0.98 | ALOX15 (0.95) | HPNMAPTALOX15SIRT5VCAM1 | |
| Probucol SCHEMBL4620631 | 0.98 | ALOX15 (0.95) | HPNMAPTALOX15SIRT5VCAM1 | |
| SCHEMBL12791592 | 0.92 | ALOX15 (0.84) | HPNMAPTALOX15SIRT5VCAM1 | |
| SCHEMBL4985953 | 0.92 | HPN (0.84) | HPNMAPTALOX15SIRT5VCAM1 | |
| Probucol SCHEMBL8344272 | 0.90 | HPN (0.81) | HPNMAPTALOX15SIRT5VCAM1 | |
| SCHEMBL4996488 | 0.90 | ALOX15 (0.81) | HPNMAPTALOX15SIRT5VCAM1 | |
| SCHEMBL9506457 | 0.88 | HPN (0.79) | HPNMAPTALOX15SIRT5VCAM1 | |
| SCHEMBL4983541 | 0.88 | ALOX15 (0.78) | HPNMAPTALOX15SIRT5VCAM1 | |
| SCHEMBL15344011 | 0.87 | ALOX15 (0.75) | HPNMAPTALOX15SIRT5VCAM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1844009-A1 | COMPOSITIONS AND METHODS FOR TREATING CARDIOVASCULAR DISORDERS | Stocker, Roland O. (AU) | 2007-10-17 | — | — | EP | disclosed |
| WO-2006063408-A1 | COMPOSITIONS AND METHODS FOR TREATING CARDIOVASCULAR DISORDERS | STOCKER RONALD O (AU) | 2006-06-22 | — | — | WO | disclosed |
| WO-2005097191-A2 | COMBINATIONS COMPRISING (S)- AMLODIPINE AND A HMG-CoA REDUCTASE INHIBITOR OR CHOLESTEROL ABSORPOTION INHIBITOR OR BOTH, AND METHODS FOR REDUCING HYPERTENSION | SEPRACOR INC. (US) | 2005-10-20 | — | — | WO | disclosed |