Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPN | P05981 | 1/20 | 0.79 |
| ▸ | MAPT | P10636 | 1/20 | 0.79 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.79 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.79 |
| ▸ | CA2 | P00918 | 4/20 | 0.56 |
| ▸ | CA1 | P00915 | 2/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | TYR | P14679 | 1/20 | 0.54 |
| ▸ | VCAM1 | P19320 | 10/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | GALR3 | O60755 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Probucol SCHEMBL4150 | 0.88 | HPN (1.00) | HPNMAPTALOX15SIRT5CA2 | |
| Probucol SCHEMBL5143451 | 0.88 | HPN (1.00) | HPNMAPTALOX15SIRT5CA2 | |
| Probucol SCHEMBL8344652 | 0.86 | ALOX15 (0.95) | HPNMAPTALOX15SIRT5CA2 | |
| Probucol SCHEMBL4620631 | 0.86 | ALOX15 (0.95) | HPNMAPTALOX15SIRT5CA2 | |
| SCHEMBL21241542 | 0.84 | HPN (0.76) | HPNMAPTALOX15SIRT5CA2 | |
| SCHEMBL3177529 | 0.81 | ALOX15 (0.71) | HPNMAPTALOX15SIRT5CA2 | |
| SCHEMBL1116345 | 0.81 | ALOX15 (0.71) | HPNMAPTALOX15SIRT5CA2 | |
| SCHEMBL4985953 | 0.81 | HPN (0.84) | HPNMAPTALOX15SIRT5CA2 | |
| SCHEMBL12791592 | 0.81 | ALOX15 (0.84) | HPNMAPTALOX15SIRT5CA2 | |
| Probucol SCHEMBL8344272 | 0.79 | HPN (0.81) | HPNMAPTALOX15SIRT5CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0293895-B1 | PHENOLIC THIOETHERS AS INHIBITORS OF 5-LIPOXYGENASE | G.D. Searle & Co. (US) | 1993-08-11 | — | — | EP | disclosed |
| US-4847305-A | Phenolic thioethers as inhibitors of 5-lipoxygenase | G. D. SEARLE & CO. (US) | 1989-07-11 | — | — | US | disclosed |
| US-4835190-A | Phenolic thioethers as inhbitors of 5-lipoxygenase | G. D. SEARLE & CO. (US) | 1989-05-30 | — | — | US | disclosed |
| EP-0293895-A1 | Phenolic thioethers as inhibitors of 5-lipoxygenase | G.D. Searle & Co. (US) | 1988-12-07 | — | — | EP | disclosed |
| US-4143076-A | MERCAPTO PHENOLIC AND ALKYLTHIO PHENOLIC ANTIOXIDANTS | THE GOODYEAR TIRE & RUBBER COMPANY (US) | 1979-03-06 | — | — | US | disclosed |
| US-4128530-A | Mercapto phenolic and alkylthio phenolic antioxidants | THE GOODYEAR TIRE & RUBBER COMPANY (US) | 1978-12-05 | — | — | US | disclosed |
| US-4128530-A | Mercapto phenolic and alkylthio phenolic antioxidants | THE GOODYEAR TIRE & RUBBER COMPANY (US) | 1978-12-05 | — | — | US | disclosed |