Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Probucol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 2/20 | 0.95 |
| ▸ | HPN | P05981 | 1/20 | 0.95 |
| ▸ | MAPT | P10636 | 1/20 | 0.95 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.95 |
| ▸ | VCAM1 | P19320 | 13/20 | 0.58 |
| ▸ | CA2 | P00918 | 4/20 | 0.56 |
| ▸ | CA1 | P00915 | 2/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | TYR | P14679 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | GALR3 | O60755 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Probucol SCHEMBL4150 | 0.98 | HPN (1.00) | ALOX15HPNMAPTSIRT5VCAM1 | |
| Probucol SCHEMBL5143451 | 0.98 | HPN (1.00) | ALOX15HPNMAPTSIRT5VCAM1 | |
| Probucol SCHEMBL8344652 | 0.95 | ALOX15 (0.95) | ALOX15HPNMAPTSIRT5VCAM1 | |
| SCHEMBL12791592 | 0.90 | ALOX15 (0.84) | ALOX15HPNMAPTSIRT5VCAM1 | |
| SCHEMBL4985953 | 0.90 | HPN (0.84) | ALOX15HPNMAPTSIRT5VCAM1 | |
| Probucol SCHEMBL8344272 | 0.88 | HPN (0.81) | ALOX15HPNMAPTSIRT5VCAM1 | |
| SCHEMBL4996488 | 0.88 | ALOX15 (0.81) | ALOX15HPNMAPTSIRT5VCAM1 | |
| SCHEMBL9506457 | 0.86 | HPN (0.79) | ALOX15HPNMAPTSIRT5VCAM1 | |
| SCHEMBL4983541 | 0.86 | ALOX15 (0.78) | ALOX15HPNMAPTSIRT5VCAM1 | |
| SCHEMBL15344011 | 0.85 | ALOX15 (0.75) | ALOX15HPNMAPTSIRT5VCAM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1851195-A4 | PROCESS FOR PREPARATION OF PROBUCOL DERIVATIVES | CAMBREX CHARLES CITY INC (US) | 2008-04-02 | — | — | EP | disclosed |
| US-7345191-B2 | Process for preparation of probucol derivatives | CAMBREX CHARLES CITY, INC. (US) | 2008-03-18 | — | — | US | disclosed |
| US-7294736-B2 | Process for preparation of probucol derivatives | CAMBREX CHARLES CITY, INC. (US) | 2007-11-13 | — | — | US | disclosed |
| EP-1851195-A1 | PROCESS FOR PREPARATION OF PROBUCOL DERIVATIVES | Cambrex Charles City, Inc. (US) | 2007-11-07 | — | — | EP | disclosed |
| EP-1756033-A4 | PROCESS FOR PREPARATION OF PROBUCOL DERIVATIVES | CAMBREX CHARLES CITY INC (US) | 2007-05-30 | — | — | EP | disclosed |
| EP-1756033-A1 | PROCESS FOR PREPARATION OF PROBUCOL DERIVATIVES | Cambrex Charles City, Inc. (US) | 2007-02-28 | — | — | EP | disclosed |
| WO-2006093501-A1 | PROCESS FOR PREPARATION OF PROBUCOL DERIVATIVES | CAMBREX CHARLES CITY, INC. (US) | 2006-09-08 | — | — | WO | disclosed |
| US-20060194875-A1 | Process for preparation of probucol derivatives | CAMBREX CHARLES CITY, INC. | 2006-08-31 | — | — | US | disclosed |
| US-20060025481-A1 | Process for preparation of probucol derivatives and polymorphic forms thereof | STRANGE MATTHEW L | 2006-02-02 | — | — | US | disclosed |
| WO-2005102985-A1 | PROCESS FOR PREPARATION OF PROBUCOL DERIVATIVES | CAMBREX CHARLES CITY, INC. (US) | 2005-11-03 | — | — | WO | disclosed |
| US-20050228192-A1 | Process for preparation of probucol derivatives | CAMBREX CHARLES CITY, INC. | 2005-10-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060025481-A1 | Process for preparation of probucol derivatives and polymorphic forms thereof | ADH1C, ADH5, CEL | ALOX15 438/4885HPN 296/4885MAPT 3166/4885 |
| US-20060194875-A1 | Process for preparation of probucol derivatives | APOB, NPC1L1, APOL1 | ALOX15 760/4885HPN 1108/4885MAPT 3600/4885 |
| US-20050228192-A1 | Process for preparation of probucol derivatives | APOB, NPC1L1, APOL1 | ALOX15 760/4885HPN 1108/4885MAPT 3600/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.